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Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic ...

Salgado, A. J.; Sousa, João Carlos; Costa, B. M.; Pires, A. O.; Mateus-Pinheiro, A.; Teixeira, F. G.; Pinto, Luísa; Sousa, Nuno

Neural stem cells (NSCs) and mesenchymal stem cells (MSCs) share few characteristics apart from self-renewal and multipotency. In fact, the neurogenic and osteogenic stem cell niches derive from two distinct embryonary structures; while the later originates from the mesoderm, as all the connective tissues do, the first derives from the ectoderm. Therefore, it is highly unlikely that stem cells isolated from one...


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