5 documents found, page 1 of 1
Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mo...
Assreuy, Ana Maria Sampaio; Adjafre, Beatriz Lima; Sousa, Évilla Rayanne Oliveira; Alves, Ana Paula Negreiros Nunes; Pires, Alana de FreitasArthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mi...
Purification and primary structure determination of a galactose-specific lectin...
Silva, Helton Colares; Nagano, C. S.; Souza, Luis A.G.; Nascimento, K. S.; Isídro, Renato; Delatorre, Plínio; Rocha, Bruno Anderson Matias daVatairea guianensis seeds, a typical plant from the Brazilian Amazon region that belongs to the Dalbergieae tribe, possess a lectin that was isolated by precipitation with solid ammonium sulfate followed by guar gum affinity chromatography. This lectin was named VGL. The V. guianensis lectin strongly agglutinated rabbit erythrocytes and was inhibited by d-galactose and d-galactose-derived sugars, especially N-a...
Contribution of the carbohydrate-binding ability of Vatairea guianensis lectin ...
Marques, Gabriela Fernandes Oliveira; Osterne, Vinicius José Silva; Almeida, Livia M.; Oliveira, Messias Vital; Brizeno, Luiz André CavalcanteVatairea guianensis lectin (VGL), Dalbergiae tribe, is a N-acetyl-galactosamine (GalNAc)/Galactose (Gal) lectin previously purified and characterized. In this work, we report its structural features, obtained from bioinformatics tools, and its inflammatory effect, obtained from a rat paw edema model. The VGL model was obtained by homology with the lectin of Vatairea macrocarpa (VML) as template, and we used it ...
Structural basis for both pro- and anti-inflammatory response induced by mannos...
Rocha, Bruno Anderson Matias da; Delatorre, Plínio; Oliveira, Taianá Maia; Benevides, R. G.; Pires, Alana de Freitas; Sousa, Albertina A.S.Legume lectins, despite high sequence homology, express diverse biological activities that vary in potency and efficacy. In studies reported here, the mannose-specific lectin from Cymbosema roseum (CRLI), which binds N-glycoproteins, shows both pro-inflammatory effects when administered by local injection and anti-inflammatory effects when by systemic injection. Protein sequencing was obtained by Tandem Mass Sp...
Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mo...
Assreuy, Ana Maria Sampaio; Adjafre, Beatriz Lima; Sousa, Évilla Rayanne Oliveira; Alves, Ana Paula Negreiros Nunes; Pires, Alana de FreitasArthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models ...