2 documents found, page 1 of 1
Potent antileukemic action of naphthoquinoidal compounds: evidence for an intri...
Cavalcanti,Bruno C.; Cabral,Igor O.; Rodrigues,Felipe A. R.; Barros,Francisco W. A.; Rocha,Danilo D.; Magalhães,Hemerson I. F.; Moura,Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β-lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor cel...
Blainvillea rhomboidea: constituintes químicos e atividade citotóxica
Gomes,Regina Ferreira; Santos,Hélcio Silva dos; Albuquerque,Maria Rose Jane R.; Pessoa,Otília Deusdênia L.; Lotufo,Leticia V. Costa; Pessoa,Claudia do ÓThe phytochemical investigation of the ethanol extract from the aerial parts of Blainvillea rhomboidea (Asteraceae) resulted in the isolation and characterization of 8β-tigloyloxy-grazielia acid, together with the flavonoids derrone, acacetin, luteolin and luteolin 7-methyl ether, and p-(1-methyl-ethan-1-ol)-phenol. The structures of all compounds were determined by spectroscopic methods (¹H and 13C NMR and HRE...