4 documents found, page 1 of 1
Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Enshea...
Gomes, Eduardo D.; Mendes, Sofia Silva; Silva, Rita Catarina Assunção Ribeiro; Teixeira, Fábio Gabriel Rodrigues; Pires, Ana O.; Anjo, Sandra I.Patients suffering from spinal cord injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies have been proposed as a viable alternative to the current treatments used. Adipose tissue-derived stromal cells (ASCs) and olfactory ensheathing cells (OECs) have been used with promising results in different models...
Old and new challenges in Parkinson's disease therapeutics
Pires, Ana O.; Teixeira, Fábio Gabriel Rodrigues; Pinheiro, Bárbara Filipa Mendes; Serra, Sofia Cravino; Sousa, Nuno; Salgado, A. J.Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and/or loss od neuronal projections, in several dopaminergic networks. Current treatments for idiopathic PD rely mainly on the use of pharmacologic agents to improve motor symptomatology of PD patients. Nevertheless, so far PD remains an incurable disease. Therefore, it is of utmost importance to e...
Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Ce...
Pires, Ana O.; Pinheiro, Bárbara Filipa Mendes; Teixeira, Fábio Gabriel Rodrigues; Anjo, Sandra; Ribeiro-Samy, Silvina; Gomes, Eduardo Domingos CorreiaThe use of human mesenchymal stem cells (hMSCs) has emerged as a possible therapeutic strategy for CNS-related conditions. Research in the last decade strongly suggests that MSC-mediated benefits are closely related with their secretome. Studies published in recent years have shown that the secretome of hMSCs isolated from different tissue sources may present significant variation. With this in mind, the presen...
The secretome of bone marrow and wharton jelly derived mesenchymal stem cells i...
Pires, Ana O.; Carvalho, Andreia Neves; Sousa, Nuno; Salgado, A. J.The goal of this study was to determine and compare the effects of the secretome of mesenchymal stem cells (MSCs) isolated from human bone-marrow (BMSCs) and the Wharton jelly surrounding the vein and arteries of the umbilical cord (human umbilical cord perivascular cells (HUCPVCs)) on the survival and differentiation of a human neuroblastoma cell line (SH-SY5Y). For this purpose, SH-SY5Y cells were differentia...