7 documents found, page 1 of 1

New therapeutic approaches to chronic kidney disease

The main research goal in patients with chronic kidney disease (CKD) is the development of new therapeutic approaches capable of slowing down the progression to end-stage renal disease. The aim of this work was to evaluate the effects of long-term administration of chaetomellic acid A (CAA), which selectively blocks H-Ras farnesylation, on chronic kidney lesions in 5/6 nephrectomized Wistar rats, an animal mode...

Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and ar...

The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5...

The effects of long-term chaetomellic acid a administration on renal function a...

This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in amodel of renalmass reduction. Methods.MaleWistar ratswere subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n = 14); RMR + CAA: RMR rats treated with CAA (n = 1...

Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and ar...

The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5...

Effect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 ne...

The high prevalence of chronic kidney disease underscores the failure to provide therapies to effectively halt, prevent, and/or reverse renal fibrosis. Thus, the aim of this study was to evaluate the effect of chronic treatment with chaethomellic acid A (CA) on renal fibrosis associated to 5/6 nephrectomy. Methods: Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after su...

Ação do ácido quetomélico nas alterações hematológicas induzidas pela redução d...

A doença renal crónica está associada com o desenvolvimento de anemia devido principalmente à diminuição da produção de eritropoetina. O ácido quetomélico (AC) é um potente inibidor seletivo da farnesil transferase e, desta forma, inibe as vias de sinalização que levam à progressão da fibrose renal. Assim, o objectivo deste trabalho foi o de estudar os efeitos do tratamento crónico com o AC nas alterações hemat...

Effects of nebivolol on liver fibrosis induced by bile duct ligation in wistar ...