51 documents found, page 1 of 6
A 3d cell culture model of the tuberculosis granuloma that can be applied for h...
David, Susana; Mandal, Manoj; Anes, Elsa; Pires, DavidIntroduction: The granuloma is an inflammatory infiltrate of mononuclear cells. Some bacterial infections are characterized by the formation of granulomas as part of the immune response to contain the infection. Granuloma models have contributed valuable insights into the genetic basis of granuloma formation during infection. For example, IFNGR1 and IFNGR2 variants have been found to disrupt the immune response...
Host-directed therapies based on protease inhibitors to control Mycobacterium t...
Mandal, Manoj; Pires, David; Azevedo-Pereira, Jose Miguel; Anes, ElsaDespite continuous and extensive global efforts in the fight against tuberculosis (TB), this infectious disease continues to exert a tremendous burden on public health concerns and deaths worldwide. TB, caused by the bacterial species Mycobacterium tuberculosis, is highly frequent in people living with HIV. The continuing epidemics of both chronic infections and the emergence of antimicrobial resistance, as wel...
Active plant nematologists (APN): cultivating collaboration, overcoming challen...
Moreira, David; Pires, David; Collett, Raymond; Orlando, Valeria; Darling, Elisabeth; Coburn, JacquelineActive Plant Nematologists (APN) is a global scientific community established during the 2020 coronavirus pandemic to address the disruption of physical conferences and meetings in the field of Plant Nematology. Committed to fostering collaborations among nematology professionals and enthusiasts, APN provides a safe space for individuals worldwide, irrespective of their position, location, or background, emphas...
Harnessing legume productivity in tropical farming systems by addressing challe...
Aguilar, Catherine Hazel; Pires, David; Cortaga, Cris; Jr., Reynaldo Peja; Cruz, Maria Angela; Langres, Joanne; Redillas, Mark Christian FelipeLegumes are among the most important crops globally, serving as a major food source for protein and oil. In tropical regions, the cultivation of legumes has expanded significantly due to the increasing demand for food, plant-based products, and sustainable agriculture practices. However, tropical environments pose unique challenges, including high temperatures, erratic rainfall, soil infertility, and a high inc...
Multiple factors associated with forest decline in the context of control measu...
Pimentel, Carla S.; Pires, David; Campôa, João; Branco, Jordana; Marques, Raquel; Mota, Manuel; Calvão, TeresaForest decline is a complex phenomenon; however, there is often a tendency to oversimplify by attributing it to a single cause, neglecting the interaction of multiple factors. Ever since the detection of the pinewood nematode (PWN), Bursaphelenchus xylophilus, in Portugal (and in Europe) over two decades ago, pine wilt cases in the country have been primarily attributed to this pathogen, leading authorities to ...
Primary bile acid shapes peripheral immunity in inflammatory bowel disease-asso...
Santos, André A.; Pires, David; Marques, Vanda; Alesina, Nicole; Herraez, Elisa; Roudnický, Pavel; Rodrigues, Pedro M.; Godinho-Santos, AnaPrimary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case–control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls....
Technological advances applied to TB vaccine development: how can AI contribute...
Pereira, João Santos; Pires, DavidTuberculosis is a long-standing global health challenge. Yet, so far, all efforts to develop an effective vaccine that surpasses the limitations of the century-old BCG vaccine have been unsuccessful. This calls for new technological solutions that can aid researchers in digesting decades of data and predict the solutions with the highest successful outcomes. This chapter discusses how Artificial Intelligence (A...
Ethambutol and meropenem/clavulanate synergy promotes enhanced extracellular an...
Olivença, Francisco; Pires, David; Silveiro, Cátia; Gama, Bianca; Holtreman, Frederico; Anes, Elsa; Catalao, Maria JoãoIncreasing evidence supports the repositioning of beta-lactams for tuberculosis (TB) therapy, but further research on their interaction with conventional anti-TB agents is still warranted. Moreover, the complex cell envelope of Mycobacterium tuberculosis (Mtb) may pose an additional obstacle to beta-lactam diffusion. In this context, we aimed to identify synergies between beta-lactams and anti-TB drugs ethambut...
Cystatin F depletion in Mycobacterium tuberculosis-infected macrophages improve...
Mandal, Manoj; Pires, David; Calado, Marta; Azevedo-Pereira, Jose Miguel; Anes, ElsaCystatin F (CstF) is a protease inhibitor of cysteine cathepsins, including those involved in activating the perforin/granzyme cytotoxic pathways. It is targeted at the endolysosomal pathway but can also be secreted to the extracellular milieu or endocytosed by bystander cells. CstF was shown to be significantly increased in tuberculous pleurisy, and during HIV coinfection, pleural fluids display high viral loa...
Synthesis, activity, toxicity, and in silico studies of new antimycobacterial N...
Pais, João P.; Antoniuk, Olha; Pires, David; Delgado, Tiago; Fortuna, Andreia; Costa, Paulo J.; Anes, Elsa; Constantino, LuisTuberculosis (TB) is a disease that plagues the frailest members of society. We have developed a family of N-alkyl nitrobenzamides that exhibit promising antitubercular activities and can be considered a structural simplification of known inhibitors of decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase (DprE1), an essential Mycobacterium tuberculosis (Mtb) enzyme and an emergent antitubercular target. Hereby, we ...