20 documents found, page 1 of 2
GENETIC CHARACTERIZATION NATIVE CATTLE OF ANGOLA USING WHOLE GENOME SEQUENCING
Sebastino, K; Chiaia, H; Teixeira, F; Gaspar, J; Afonso, P; Cláudio, S; Nanga, P; Pires, J; Adelino, M; Ngola, S; Casimiro, J; Gomes, L; Dala, EIn Angola, about 70% of the population relies on subsistence agriculture, with cattle production crucial to the economy and culture of the southern regions. Local cattle breeds face extinction due to crossbreeding with improved breeds or replacement by exotic commercial breeds, risking the loss of unique genetic traits vital for adapting to Angola's ecosystems. This project aims to establish a biobank represent...
GENETIC DIVERSITY OF NATIVE GOATS (CAPRA HIRCUS) FROM ANGOLA AND IDENTIFICATION...
Chiaia, H; Sebastino, K; Afonso, P; Gaspar, J; Teixeira, F; Ngola, S; Simão, C; Casimiro, J; Nanga, P; Pires, J; Miguel, Adelino; Gomes, LadislauIn Angola, about 70% of the population relies on subsistence agriculture, with cattle production crucial to the economy and culture of the southern regions. Local cattle breeds face extinction due to crossbreeding with improved breeds or replacement by exotic commercial breeds, risking the loss of unique genetic traits vital for adapting to Angola's ecosystems. This project aims to establish a biobank represent...
Genetic signatures of selection in southern Angolan sheep unravel adaptation fo...
Teixeira, F; Chiaia, H; Sebastino, K; Gaspar, J; Afonso, P; Ngola, S; Simão, C; Casimiro, J; Pires, J; Miguel, A; Dala, E; Pires, M; Nanga, P; Santos, DNatural and artificial selection in African sheep populations has left distinctive genomic signatures. In southern Angola, pastoralist tribes breed fat-tailed sheep adapted to arid and mesic savannas for protein and cultural purposes. This study aims to identify candidate genes associated with productivity and adaptation in these sheep. We sequenced genomes from Namibe (n = 3) and Cunene (n = 5) and compared th...
Cumulus cell DNA damage linked to fertilization success in females with an ovul...
Rodrigues, B; Sousa, V; Esteves, F; Vale-Fernandes, E; Costa, S; Sousa, D; Brandão, R; Leal, C; Pires, J; Gaivão, I; Teixeira, JP; Nogueira, AJAIntracytoplasmic sperm injection (ICSI) is a widely used technique in fertility centers. ICSI success depends on both nuclear and cytoplasmic oocyte maturation. Cumulus cells, which surround the oocytes, play a pivotal role in oocyte competence. However, the significance of DNA damage in cumulus cells as a marker of fertilization success remains largely unexplored. This study aims to investigate the relationshi...
Extracellular vesicles in tumor-adipose tissue crosstalk: key drivers and thera...
Ramos, CC; Pires, J; Gonzalez, E; Garcia-Vallicrosa, C; Reis, CA; Falcon-Perez, JM; Freitas, DCancer cachexia is a complex metabolic syndrome characterized by unintentional loss of skeletal muscle and body fat. This syndrome is frequently associated with different types of cancer and negatively affects the prognosis and outcome of these patients. It involves a dynamic interplay between tumor cells and adipose tissue, where tumor-derived extracellular vesicles (EVs) play a crucial role in mediating inter...
COVID-19: Impact of the Pandemic on Children’s Lives
Roquette, M; Jonet, J; Pires, J; Paes-Vasconcellos, AIntroduction: The COVID-19 pandemic has had a considerable impact on the biopsychosocial elements of human beings, especially children and teenagers, as vulnerable groups. Social isolation can lead to psychiatric illness, obesity, and sleep disorders in adults. This study aimed to determine the impact of lockdown on children’s sleep, diet, physical activity, and behavior. Methods: This was a retrospective obser...
Differential Protein and Glycan Packaging into Extracellular Vesicles in Respon...
Martins, ÁM; Lopes, TM; Diniz, F; Pires, J; Osorio, H; Pinto, F; Freitas, D; Reis, CAAlterations of the glycosylation machinery are common events in cancer, leading to the synthesis of aberrant glycan structures by tumor cells. Extracellular vesicles (EVs) play a modulatory role in cancer communication and progression, and interestingly, several tumor-associated glycans have already been identified in cancer EVs. Nevertheless, the impact of 3D tumor architecture in the selective packaging of ce...
Comet assay
Costa, S; Pires, J; Teixeira-Gomes, AThe comet assay is a sensitive, inexpensive, fast, and easy-to-use method widely used in genotoxicity testing and biomonitoring studies. It can be applied using a few cells and on almost every cell type to assess a range of different DNA lesions, DNA repair activity and even DNA methylation levels, at the individual cell level. The principle is simple, during electrophoresis relaxed DNA strands move toward the ...
A Novel Plant-Based Protein Has Similar Effects Compared to Whey Protein on Bod...
Teixeira, FJ; Matias, CN; Faleiro, J; Giro, R; Pires, J; Figueiredo, H; Carvalhinho, R; Monteiro, CP; Reis, JF; Valamatos, MJ; Teixeira, Vitor HugoIntroductionThe effects of dietary protein on body composition and physical performance seemingly depend on the essential amino acid profile of the given protein source, although controversy exists about whether animal protein sources may possess additional anabolic properties to plant-based protein sources. PurposeTo compare the effects of a novel plant-based protein matrix and whey protein supplementation on ...
A large multi-country outbreak of monkeypox across 41 countries in the WHO Euro...
Vaughan, AM; Cenciarelli, O; Colombe, S; de Sousa, LA; Fischer, N; Gossner, CM; Pires, J; Scardina, G; Aspelund, G; Avercenko, M; Bengtsson, SFollowing the report of a non-travel-associated cluster of monkeypox cases by the United Kingdom in May 2022, 41 countries across the WHO European Region have reported 21,098 cases and two deaths by 23 August 2022. Nowcasting suggests a plateauing in case notifications. Most cases (97%) are MSM, with atypical rash-illness presentation. Spread is mainly through close contact during sexual activities. Few cases a...