2 documents found, page 1 of 1
Preclinical assessment of mesenchymal-stem-cell-based therapies in spinocerebel...
Correia, Joana Sofia Silva; Carvalho, Andreia Alexandra Neves; Pinheiro, Bárbara Filipa Mendes; Pires, Joel Pereira; Teixeira, Fábio Gabriel RodriguesThe low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies for neurodegenerative diseases, including spinocerebellar ataxias. Spinocerebellar ataxia type 3 (SCA3)—or Machado–Joseph disease (MJD)—is the most common dominant ataxia, being mainly characterized by motor deficits; however, SCA3/MJD has a complex and heterogeneous pathop...
Histamine modulates nitric oxide release by microglia and dopaminergic neuronal...
Pires, Joel PereiraMicroglia cells, the resident immune cells in the brain, play a critical role in the development and progression of several neurodegenerative diseases. Parkinson's disease (PD) is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons (DA) in the substantia nigra (SN), striatal dopamine depletion and motor impairments. Accumulating clinical and experimental evidences suggest that ...