26 documents found, page 1 of 3
Exploring the therapeutical potential of Quercus ilex extract in papillomavirus...
Medeiros-Fonseca, B; Faustino-Rocha, AI; Pires, MJ; Gil da Costa, RM; Oliveira, PABackground and Aim: Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have...
Quercus spp. extract as a promising preventive or therapeutic strategy for canc...
Oliveira, Paula A.; Vasconcelos-Nóbrega, C; Pires, MJ; Vala, H; Barros, AIRNA; Faustino-Rocha, Ana IAcorns have traditionally been used in the human diet and for the treatment of specific diseases. Therefore, the present study performed a systematic review of studies which investigated the effects of Quercus spp. extracts in cancer prevention and treatment. A systematic literature search was performed for original records which addressed the anticancer effects of Quercus spp. extract in in vitro and in vivo c...
Appraising animal models of prostate cancer for translational research: future ...
Nascimento-Gonçalves, E; Seixas, F; Gil da Costa, R; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, D; Fardilha, M; Faustino-Rocha, Ana I; Colaço, BThe growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testos...
The role of natural compounds in rat mammary cancer: the beneficial effects of ...
Azevedo, Tiago; Silva, J; Faustino-Rocha, Ana I; Valada, A; Anjos, L; Moura, T; Ferreira, T; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, FBreast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, includ- ing anticancer and anti-diabetic properties. This study aimed to assess the chemopreven- tive effects of S. chamaecyparissus aqueous ex- tract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were...
Lifelong exercise training promotes the remodelling of the immune system and pr...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, DThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administratio...
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, C; Silva, AR; Ferreira, T; Barros, L; Neuparth, MJ; Peixoto, F; Bastos, MMSM; Medeiros, R; Gil da Costa, RM; Pires, MJ; Faustino-Rocha, Ana Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic comp...
Assessing the in vivo effects of Pteridium aquilinum extract in K14-HPV16 trans...
Medeiros-Fonseca, B; Faustino-Rocha, Ana I; Pires, MJ; Queiroga, F; Medeiros, R; Gil da Costa, RM; Oliveira, PAPteridium aquilinum, commonly known as bracken fern, is a versatile plant species that thrive in diverse environmental conditions and has a global distribution. However, it possesses toxic properties that can lead to various diseases in animals. The consumption of bracken fern has been associated with the development of gastrointestinal and bladder tumours, thiamine deficiency, retinal degeneration, and haemorr...
Moderate intensity treadmill exercise influences the immune system and prostate...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJMaterial & Methods: Fifty-five male Wistar rats were divided into: control sedentary (SED+CONT; n=10), control exercised (EX+CONT; n=10), induced sedentary (SED+PCa; n=15), and induced exercised (EX+PCa; n=20). Exercised animals were trained in a treadmill, for 53 weeks. PCa induction consisted of flutamide and N-methyl-N-nitrosourea administration, followed by testosterone propionate implants. At sacrifice, pr...
Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemica...
Azevedo, T; Faustino-Rocha, Ana I; Silva, J; Valada, A; Anjos, L; Moura, T; Ferreira, R; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F; Seixas, FChemopreventive effects of Santolina chamaecyparissus in a rat model of chemically- induced mammary cancer
Immune system and prostate signalome in a rat model of prostate cancer: influen...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJImmune system and prostate signalome in a rat model of prostate cancer: influence of lifelong exercise training