7 documents found, page 1 of 1
Intertextuality and Identity in the Literary Works of Boris Vian and Al Tayeb S...
Pires, ManuelThis article discusses the winding road of intertextuality in the literary works I Spit on Your Graves, by Boris Vian (published under the pseudonym of Vernon Sullivan) and Season of Migration to the North, by Al Tayeb Salih. Published twenty years apart in the midtwentieth century, both works use different contexts and references to address issues related to the construction of racial identity within colonial ...
Peripheral neuropathy in systemic vasculitis and other autoimmune diseases – a ...
Rodrigues, Rita; Branco, Mariana; Silva, Renata; Ruano, Luís; Fontão, Luís; Lopes, Marta; Scigliano, Horácio; Taipa, Ricardo; Pires, ManuelIntroduction: Peripheral neuropathies may present in the context of systemic vasculitis and other autoimmune diseases. The etiologic characterization is crucial to define the treatment and prognosis in secondary vasculitis. The purpose of this study is to describe the pathway of etiologic investigation including the role of nerve biopsy. Methods: Retrospective analysis of patients seen in the neuromuscular outp...
Usher syndrome and Nebulin‐associated myopathy in a single patient due to varia...
Maia, N; Soares, Ana Rita; Fortuna, Ana; Marques, Isabel; Gonçalves, Ana; Santos, Rosário; Pires, Manuel; De Brouwer, Arjan; Jorge, PaulaIn a patient with Usher syndrome and atypical muscle complaints, we have identified two separate variants in MYO7A andNEB genes by exome sequencing. The homozygous variants in these two recessive genes could explain the full phenotype of our patient.
A novel molecular link between HOXA9 and WNT6 in glioblastoma identifies a subg...
Gonçalves, Céline S.; Xavier‐Magalhães, Ana; Martins, Eduarda P.; Pinto, Afonso A.; Pires, Manuel; Pinheiro, Célia; Reis, Rui M.; Sousa, NunoDespite much effort to improve treatments, patients with malignant glioma still present a very poor prognosis that has not changed significantly in the last decades. In this context, it is crucial to better understand glioma pathogenesis to identify new molecular prognostic subgroups and therapeutic targets. WNT6 was recently identified as a new oncogenic molecule in glioblastoma (GBM), with prognostic value in...
Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas an...
Moniz, Sónia; Martinho, Olga; Pinto, Filipe; Sousa, Bárbara; Loureiro, Cláudia; Oliveira, Maria José; Moita, Luís Ferreira; Honavar, MrinaliniThe gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a signalling guanosine triphosphatase involved in cell migration and motility. Here we show that WNK2 promoter methyl...
Tarefas de investigação na sala de aula de Matemática: práticas de uma professo...
Pires, ManuelO presente texto descreve uma experiência lectiva, desenvolvida no âmbito do Programa de Formação Contínua em Matemática, com o propósito principal de conhecer como os professores integram as tarefas de investigação no desenvolvimento do currículo e como reflectem sobre as suas práticas. O estudo segue uma abordagem qualitativa e interpretativa e centra-se no trabalho de uma professora de Matemática do 2.º cicl...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...