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siRNA inhibition of endocytic pathways to characterize the cellular uptake mech...

Pereira, Paula; Pedrosa, Sílvia Santos; Wymant, Jennifer M.; Sayers, Edward; Correia, Alexandra; Vilanova, Manuel; Jones, Arwin T.; Gama, F. M.

Glycol chitosan nanogels have been widely used in gene, drug, and contrast agent delivery in an effort to improve disease diagnosis and treatment. Herein, we evaluate the internalization mechanisms and intracellular fate of previously described glycol chitosan nanogels decorated with folate to target the folate receptor. Uptake of the folate-decorated nanogel was impaired by free folate, suggesting competitive ...


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