Introduction: Neurodegenerative disorders, such as Alzheimer’s disease (AD) and frontotemporal dementia (bvFTD), reflect a spectrum of cognitive impairments unified by cognitive decline. Traditional diagnostic approaches often overlook shared landscapes of these disorders. A transdiagnostic approach, cutting across conventional boundaries, may improve understanding of shared mechanisms. This study uses lesion-s...
Introdução: A Dupla Tarefa (DT) é uma intervenção terapêutica que tem demonstrado grande eficácia na recuperação da marcha após AVE. Objetivo: Sumariar os efeitos do treino da dupla tarefa na melhoria dos parâmetros da marcha em adultos após AVE. Metodologia: Realizou-se uma pesquisa computorizada, entre Dezembro de 2019 e Janeiro de 2020, nas bases de dados e motores de busca PubMed, PEDro e MEDLINE, para enco...
Cell-penetrating peptides (CPPs) have been applied as novel transport systems with the ability to facilitate the delivery of peptides, proteins, and oligonucleotides into cells. Herein, we designed different fusion proteins composed by pig odorant binding protein (OBP-I) and three CPPs, namely Tat, pVEC and Pep-1. A new methodology using liposomes as reservoirs and OBP:CPPs as carriers was developed as an advan...
In the intertidal seagrass beds of Zostera noltii of Mira estuary (SW, Portugal) the harvesting practices are frequent. The traditional bivalve harvesting not only affects the target species as the remaining biological assemblages. The main aim of this study was to assess the disturbance caused by sediment digging in the recovery of the seagrass beds habitat, through an experimental fieldwork. The responses of ...
O relatório apresentado está dividido em dois capítulos, sendo que o Capítulo I diz respeito ao estágio em Farmácia Comunitária (FC) e o Capítulo II tem que ver com o estágio em Farmácia Hospitalar (FH). O estágio em FC decorreu, entre 1 de novembro de 2017 e 26 de janeiro de 2018, na Farmácia Progresso, situada em Castelo Branco, tendo a duração de 412 horas. Este estágio foi orientado pedagogicamente pela pro...
In the intertidal seagrass beds of Zostera noltii of Mira estuary (SW, Portugal) the harvesting practices are frequent. The traditional bivalve harvesting not only affects the target species as the remaining biological assemblages. The main aim of this study was to assess the disturbance caused by sediment digging in the recovery of the seagrass beds habitat, through an experimental fieldwork. The responses of ...
Introduction: DNA damaging agents and ionizing radiation used in the therapy of human cancers can induce senescence of cancer cells. Senescent cells exhibit a secretory phenotype (senescence-associated secretome [SAS]) that can affect cancer cell behavior and, eventually, clinical prognosis. We assessed the effects of the SAS on the induction of epithelial-to-mesenchymal transition (EMT) in vitro and in clinica...
Introduction: Surgery is the only potentially curative treatment for patients with colorectal liver metastases, resulting in 5-year survival rates of 36–58%. Although many studies have been performed to determine prognostic factors for tumor recurrence and survival after resection of colorectal liver metastases, there are few prognostic scoring systems stratifying patients undergoing surgery for colorectal live...
Actualmente, os métodos mais eficazes de remoção de cianotoxinas envolvem o uso de tecnologias dispendiosas. Os carvões activados são ainda de elevado custo pelo que a procura de adsorventes alternativos é o foco de estudos de tratamento de águas destinadas ao consumo humano. O presente trabalho tem como objectivo a avaliação do potencial de utilização de granulados de cortiça para a remoção de MCLR. Para isso,...