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Cyclic ACTH-secreting thymic carcinoid: a case report and review of the literature
Lamback,Elisa B.; Almeida,Sérgio Altino de; Terra,Ricardo; Ferreira,Carlos Gil; Capelozzi,Vera Luiza; Haddad,Rui; Gadelha,Mônica R.SUMMARY Cyclic Cushing's syndrome (CS) due to thymic carcinoid is a rare disorder. We report a case of cyclic CS due to ectopic adrenocorticotropic hormone (ACTH)-secreting atypical thymic carcinoid tumor and reviewed similar cases published in the literature. Our patient had hypercortisolemia lasting approximately one month, followed by normal cortisol secretion, with relapse one year later. Histopathology rev...
Apoplexy in sporadic pituitary adenomas: a single referral center experience an...
Fialho,Christhiane; Barbosa,Monique Álvares; Lima,Carlos Henrique Azeredo; Wildemberg,Luiz Eduardo Armondi; Gadelha,Mônica R.; Kasuki,LeandroABSTRACT Objective: To analyze the clinical, laboratory, and radiological findings and management of patients with clinical pituitary apoplexy and to screen for aryl hydrocarbon receptor-interacting protein (AIP) mutations. Subjects and methods: The clinical findings were collected from the medical records of consecutive sporadic pituitary adenoma patients with clinical apoplexy. Possible precipitating factors,...
Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor assoc...
Lamback,Elisa B.; Henriques,Daniel G.; Vazquez-Borrego,Mari C.; Lima,Carlos H. de Azeredo; Kasuki,Leandro; Luque,Raul M.; Chimelli,LeilaSUMMARY Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pitu...
A review on the diagnosis and treatment of patients with clinically nonfunction...
Vieira Neto,Leonardo; Boguszewski,Cesar L.; Araújo,Luiz Antônio de; Bronstein,Marcello D.; Miranda,Paulo Augusto C.; Musolino,Nina R. de C.ABSTRACT Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Other presentation...
Experience with pegvisomant treatment in acromegaly in a single Brazilian terti...
Kasuki,Leandro; Machado,Evelyn de Oliveira; Ogino,Liana Lumi; Coelho,Maria Caroline Alves; Silva,Cintia Marques dos SantosABSTRACT Objective To describe the safety and efficacy of pegvisomant therapy and the predictors of treatment response in acromegaly patients at a single tertiary reference center in Brazil. Materials and methods We retrospectively reviewed the clinical, hormonal and radiological data of acromegaly patients treated with pegvisomant in our center. We also evaluated the presence of the d3 isoform of the growth ho...
Insulin-like growth factor (IgF)-I, IgF binding protein-3, and prostate cancer:...
Corrêa,Lívia L.; Vieira Neto,Leonardo; Lima,Giovanna A. Balarini; Gabrich,Rafael; Miranda,Luiz Carlos D. de; Gadelha,Mônica R.Introduction Non-androgenic growth factors are involved in the growth regulation of prostate cancer (PCa). Objective This is the first Brazilian study to correlate, in a population of patients operated for PCa, PSA, total testosterone, insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-3 (IGFBP-3) with Gleason score and to compare with a control group with benign prostate hyperp...