46 documents found, page 1 of 5

In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therap...

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance. Considering that chromene-based scaffolds proved to be attractive candidates for cancer therapy, herein we prepared new chromeno[2,3-d]pyrimidinone derivatives by a simple two step procedure, sta...

COVID-19, the Reality of an Internal Medicine Ward

Introduction: The reorganization of health care imposedby the COVID-19 pandemic revealed the work capacity of all health professionals, mirroring the fundamental role of Internal Medicine. This work intended to highlight the complexity of managing the COVID-19 patient, often guided by the absence of theoretical/scientific support in the face of the unknown. Methods: A retrospective and descriptive evaluation of...

A Peculiar Case of Neuroborreliosis

A doença de Lyme é uma zoonose endémica em algumas regiões do hemisfério norte, como o continente europeu. Trata-se de uma doença multissistémica com manifestações cutâneas, articulares, cardíacas e neurológicas, variáveis, de acordo com o estadio da doença. O envolvimento do sistema nervoso designa-se por neuroborreliose de Lyme. É dividida em precoce e tardia. A neuroborreliose precoce apresenta uma tríade cl...

Conversas informais de cerveja na mão: sucessos e desafios do PubhD em Portugal

O PubhD chegou a Portugal há quase uma década. Desde então desafiou centenas de estudantes de doutoramento de diversas áreas científicas a partilhar os seus projetos de Doutoramento no ambiente informal de um bar, Aveiro, Braga, Bragança, Coimbra, Évora, Guimarães, Lisboa, Porto e Viana do Castelo já receberam esta iniciativa. Em algumas delas o sucesso não perdurou, noutros casos as equipas conseguiram reinven...

Smooth Muscle Tumours of the Uterus: MR Imaging Malignant Predictive Features-a...

Purpose: To evaluate the magnetic resonance imaging (MRI) features that may help distinguish leiomyosarcomas from atypical leiomyomas (those presenting hyperintensity on T2-W images equal or superior to 50% compared to the myometrium). Materials and methods: The authors conducted a retrospective single-centre study that included a total of 57 women diagnosed with smooth muscle tumour of the uterus, who were eva...

Gastrointestinal Metastatic Melanoma: The Key for Diagnosis

Worker 4.0: A textile exoskeleton to support apparel industry

STVgoDigital project aims the transition of the textile and apparel industries to the new Industry 4.0 paradigm promoting the digitalization to increase productivity and efficiency of the entire value chain. Specifically, the PPS4 Worker 4.0 aims to develop an exoskeleton solution based on sensing and active components within a garment to support sewing operation movements that may cause injuries and/or pain in...

Sustainable fluorescent dye-faujasite zeolite systems as tools for cancer bioim...

The use of fluorescent nanoparticles for biological and medical applications has attracted great attention due to their several advantages compared to conventional fluorescent dyes. However, there is also a need for sustainable and versatile alternatives, alongside the streamlining of complex synthesis or preparations. In this work, we study the potential of the faujasite zeolite structure to encapsulate dye mo...

Glucose metabolism reprogramming in bladder cancer: hexokinase 2 (HK2) as progn...

Proliferating cancer cells are able to reprogram their energy metabolism, favouring glycolysis even in the presence of oxygen and fully functioning mitochondria. Research is needed to validate the glycolysis-related proteins as prognostic/predictive biomarkers in urothelial bladder carcinoma (UBC), a malignancy tagged by high recurrence rates and poor response to chemotherapy. Here, we assessed GLUT1, HK2, PFKL...

Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple...

Triple negative breast cancer (TNBC) is a highly heterogenous disease not sensitive to endocrine or HER2 therapy and standardized treatment regimens are still missing. Therefore, development of novel TNBC treatment approaches is of utmost relevance. Herein, the potential of MAPK/ERK downregulation by RNAi-based therapeutics in a panel of mesenchymal stem-like TNBC cell lines was uncovered. Our data revealed tha...