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Preconditioning with L-alanyl-L-glutamine in a Mongolian Gerbil model of acute ...

Pires,Vilma Leite de Sousa; Souza,José Reniclebson Feitosa de; Guimarães,Sergio Botelho; Silva Filho,Antonio Ribeiro da; Garcia,José Huygens Parente

PURPOSE: To investigate the effect of L-alanyl-L-glutamine (L-Ala-Gln) preconditioning in an acute cerebral ischemia/reperfusion (I/R) model in gerbils. METHODS: Thirty-six Mongolian gerbils (Meriones unguiculatus), (60-100g), were randomized in 2 groups (n=18) and preconditioned with saline 2.0 ml (Group-S) or 0.75g/Kg of L-Ala-Gln, (Group-G) administered into the femoral vein 30 minutes prior to I/R. Each gro...

Date: 2011   |   Origin: Oasisbr
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