11 documents found, page 1 of 2
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and l...
Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; Papegaey, AnthonyCaffeine is the most consumed psychoactive substance worldwide. Strikingly, molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal-omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippocampus, at the...
Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral ne...
Dewaeles, Edmone; Carvalho, Kévin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, HariharanCisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent medical need to identify novel strategies that limit cisplatin-induced toxicity. In the present study, we show th...
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and l...
Paiva, Isabel; Cellai, Lucrezia; Meriaux, Céline; Poncelet, Lauranne; Nebie, Ouada; Saliou, Jean-Michel; Lacoste, Anne-Sophie; Papegaey, AnthonyCaffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in the mouse hippocampus using untargeted orthogonal omics techniques. Our results revealed that chronic caffeine exerts concerted pleiotropic effects in the hippo...
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of ...
Cristiano Brigas, Maria Helena; Ribeiro, Miguel; Coelho, Joana E; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, EmilieNeuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, but the contribution of the recently described meningeal immune population to AD pathogenesis remains to be addressed. Here, using the 3xTg-AD model, we report an accumulation of interleukin-17 (IL-17)-producing cells, mostly γδ T cells, in the brain and the meninges of female, but not male, mic...
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pat...
Carvalho, Kevin; Faivre, Emilie; Pietrowski, Marie J.; Marques, Xavier; Gomez-Murcia, Victoria; Deleau, Aude; Huin, Vincent; Hansen, Jan NAccumulating data support the role of tau pathology in cognitive decline in ageing and Alzheimer's disease, but underlying mechanisms remain ill-defined. Interestingly, ageing and Alzheimer's disease have been associated with an abnormal upregulation of adenosine A2A receptor (A2AR), a fine tuner of synaptic plasticity. However, the link between A2AR signalling and tau pathology has remained largely unexplored....
Beneficial effect of a selective adenosine A2A receptor antagonist in the APPsw...
Faivre, Emilie; Coelho, Joana E; Zornbach, Katja; Malik, Enas; Baqi, Younis; Schneider, Marion; Cellai, Lucrezia; Carvalho, Kevin; Sebda, ShéhérazadeConsumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease. While short-term treatment with A2AR antagonists have been shown to alleviate cognitive deficits in mouse models of amyloidogenesis, impact of a chronic and long-term treatment on the devel...
Age-related shift in LTD is dependent on neuronal adenosine A2A receptors inter...
Temido Ferreira, Mariana; Ferreira, Diana; Batalha, Vânia; Marques-Morgado, Inês; Coelho, Joana E; Pereira, Pedro; Gomes, Rui; Pinto, AndreiaSynaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the cognitive decline. An association between a polymorphism of the adenosine A2A receptor (A2AR) encoding gene-ADORA2A, and hippocampal volume in AD patients was recently described. In this study, we explore the synaptic function of A2AR in age-related conditions. We report, for the first time, a significant overexpression o...
Atypical, non-standard functions of the microtubule associated Tau protein
Sotiropoulos, I.; Galas, Marie-Christine; Silva, Joana Margarida Gonçalves Mota; Skoulakis, Efthimios; Wegmann, Susanne; Maina, Mahmoud BukarSince the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizati...
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfuncti...
Batalha, Vânia; Ferreira, Diana; Coelho, Joana E; Valadas, Jorge S.; Gomes, Rui; Temido Ferreira, Mariana; Shmidt, Tatiana; Baqi, Younis; Buée, LucCaffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A2AR therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticosterone circadian lev...
Dysregulation of TrkB receptors and BDNF function by amyloid-β peptide is media...
Jerónimo-Santos, André; Vaz, Sandra H.; Parreira, Sara; Lerias, Sofia; Caetano, António P.; Buée-Scherrer, Valérie; Castrén, Eero; Valente, Cláudia A.Brain-derived neurotrophic factor (BDNF) and its high-affinity full-length (FL) receptor, TrkB-FL, play a central role in the nervous system by providing trophic support to neurons and regulating synaptic plasticity and memory. TrkB and BDNF signaling are impaired in Alzheimer's disease (AD), a neurodegenerative disease involving accumulation of amyloid-β (Aβ) peptide. We recently showed that Aβ leads to a decr...