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Skin in vitro models to study dermal white adipose tissue role in skin healing
Lago, M. E. L.; Cerqueira, M. T.; Pirraco, R. P.; Reis, R. L.; Marques, A. P.The perception of the role of adipose tissue has been changing over the years. For a long time, it was simply seen as an energy storage organ that confers mechanical protection and heat insulation. However, an increasing number of studies demonstrate the complex role of adipose tissue in the systemic regulation of processes such as immunity and inflammation. Therefore, adipose tissue is currently considered a m...
Marine collagen/apatite composite scaffolds envisaging hard tissue applications
Diogo, G. S.; Senra, E. L.; Pirraco, R. P.; Canadas, R. F.; Fernandes, E. M.; Serra, J.; Pérez-Martín, R. I.; Sotelo, C. G.; Marques, A. P.The high prevalence of bone defects has become a worldwide problem. Despite the significant amount of research on the subject, the available therapeutic solutions lack efficiency. Autografts, the most common used approaches to treat bone defects have limitations such as donor site morbidity, pain and lack of donor site. Marine resources emerge as an attractive alternative to extract bioactive compounds for fu...
In vivo osteogenic differentiation of stem cells inside compartmentalized capsu...
Correia, C.; Santos, T. C.; Pirraco, R. P.; Cerqueira, M. T.; Marques, A. P.; Reis, R. L.; Mano, J. F.Capsules coated with polyelectrolytes and co-encapsulating adipose stem (ASCs) and endothelial (ECs) cells with surface modified microparticles are developed. Microparticles and cells are freely dispersed in a liquified core, responsible to maximize the diffusion of essential molecules and allowing the geometrical freedom for the autonomous three-dimensional (3D) organization of cells. While the membrane wraps ...
In vitro characterization on the interactions between carboxymethyl-chitosan/po...
Oliveira, Joaquim M.; Salgado, A. J.; Pirraco, R. P.; Pereira, V. H.; Fraga, J. S.; Marques, A. P.; Neves, N. M.; Mano, J. F.; Reis, R. L.; Sousa, Nuno[Excerpt] Central nervous system associated disorders are a leading cause of disability worldwide. In recent years targeted drug delivery nanoparticle based systems for intracellular application have been put forward has a possible therapeutic route to follow. In this sense the objective of the present report was to characterize and evaluate the possible applicability of recently developed carboxymethylchitosan...
Development and characterization of osteogenic cell sheets in an in vivo model
Pirraco, R. P.; Yamato, M.; Marques, A. P.; Reis, R. L.; Okano, T.[Excerpt] Despite some successes in the tissue engineering field its evolution seems to be tampered by limitations such as cell sourcing and the lack of adequate scaffolds to support cell growth and differentiation. The use of stem cells combined with cell sheet engineering technology seems a promising way to overcome these limitations. In this work bone marrow cells were flushed from 3 weeks old Wistar rat fem...