3 documents found, page 1 of 1
Quality by Design Approach for the Development of Liposome Carrying Ghrelin for...
Barros, Cecília de; Aranha, Norberto; Severino, Patrícia; Souto, Eliana B.; Zielińska, Aleksandra; Lopes, André; Rios, Alessandra; Batain, FernandoThe therapeutic use of peptides has increasingly recognized in the development of new therapies. However, the susceptible enzymatic cleavage is a barrier that needs to overcome. Nose-to-brain delivery associated with liposomes can protect peptides against biodegradation and improve the accessibility to brain targets. The aim was to develop a liposomal formulation as ghrelin carrier. The quality by design (QbD) ...
Nanopesticides in agriculture: benefits and challenge in agricultural productiv...
Chaud, Marco; Souto, Eliana B.; Zielinska, Aleksandra; Severino, Patricia; Batain, Fernando; Oliveira-Junior, Jose; Alves, ThaisNanopesticides are nanostructures with two to three dimensions between 1 to 200 nm, used to carry agrochemical ingredients (AcI). Because of their unique properties, the loading of AcI into nanoparticles offers benefits when compared to free pesticides. However, with the fast development of new engineered nanoparticles for pests control, a new type of environmental waste is being produced. This paper describes ...
Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepa...
Bignotto, Leticia; Rocha, Joao; Sepodes, Bruno; Eduardo-Figueira, Maria; Pinto, Rui; Chaud, Marco; de Carvalho, Joao; Moreno, Heitor,The regular intake of tomatoes or its products has been associated with a reduced risk of chronic diseases and these effects have been mainly attributed to lycopene. Here, we evaluated the anti-inflammatory properties of lycopene and its protective effects on organ injury in two experimental models of inflammation. In order to study the effects of lycopene in local inflammation, a carrageenan-induced paw oedema...