4 documents found, page 1 of 1
Synthesis of selenium-quinone hybrid compounds with potential antitumor activit...
Jardim, Guilherme A. M.; Cruz, Eduardo H. G. da; Valença, Wagner O.; Lima, Daisy J. B.; Cavalcanti, Bruno C.; Pessoa, Claudia; Rafique, JamalAbstract: In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), ...
One-Pot Synthesis of Benzopyran-4-ones with Cancer Preventive and Therapeutic P...
Talhi, Oualid; Brodziak-Jarosz, Lidia; Panning, Jana; Orlikova, Barbora; Zwergel, Clemens; Tzanova, Tzvetomira; Philippot, StephanieA one-pot synthesis of novel benzopyran-4-ones is described. In a tandem reaction, organobase-catalysed Michael addition of (RCOCH2COR2)-C-1 on chromone-3-carboxylic acid led to decarboxylation and pyran-4-one ring opening of the latter. This was followed by chromone- and/or chromanone ring closure of the resulting Michael adducts when R-1 is an ortho-hydroxyaryl group. Antioxidant testing of 14 derivatives ide...
Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines p...
Talhi, Oualid; Schnekenburger, Michael; Panning, Jana; Pinto, Diana G. C.; Fernandes, José A.; Almeida Paz, Filipe A.; Jacob, Claus; Diederich, MarcSynthesis of the bis-4-hydroxycoumarin-type compound, 3,3'-[3-(2-hydroxyphenyl)-3-oxopropane-1,1-diyl] bis(4-hydroxy-2H-chromen-2-one), was performed by two alternative pathways, either involving a basic organocatalyzed 1,4-conjugate addition tandem reaction of 4-hydroxycoumarin on chromone-3-carboxylic acid, or a double condensation of 4-hydroxycoumarin on omega-formyl-2'-hydroxyacetophenone. The anti-prolifer...
Synthesis of new organochalcogen (Se or Te) based multifunctional pyrimidine de...
Arora, Ekta; Bhasin, K. K.; Mehta, S. K.; Sharma, Nidhi; Bhasin, A. K. K.; Jacob, Claus; Felix, Vitor; Neogi, SubhadipA new class of multinucleate pyrimidine chalcogen (Se/Te) derivatives, i.e. 2,4-bis(arylchalcogenyl)pyrimidine and 2-chloro-4,6-bis(arylchalcogenyl)pyrimidine compounds, has been synthesized for the first time by the nucleophilic substitution of chlorine at the C-2 and C-4 positions of 2,4-dichloropyrimidine and at the C-4 and C-6 positions of 2,4,6-trichloropyrimidine with a variety of chalcogen bearing aryl a...