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Short-communication: study of fatty acid metabolites in microbial conjugated fa...
Fontes, Ana Luiza; Neves, Bruna; Conde, Tiago; Couto, Daniela; Pimentel, Lígia Leão; Rodríguez-Alcalá, Luis Miguel; Domingues, M. RosárioMicrobially enriched food in conjugated linoleic (CLA) and conjugated linolenic (CLNA) acids is intensively studied nowadays. The conversion of linoleic (LA) and α-linolenic acids (α-LNA) into these compounds may involve different fatty acid (FA) intermediates. This research aimed to investigate potential FA byproducts in milk during microbial CLA/CLNA-enrichment using Bifidobacterium breve DSM 20091. Milk ferm...
Study of the association between genotypic potential and linoleic acid toleranc...
Fontes, Ana Luiza; Pimentel, Lígia Leão; Calzada, Javier; Salsinha, Ana Sofia; Rodríguez, Juan Miguel; Gomes, Ana Maria; Arqués, Juan L.Probiotic bacteria have been shown to produce the bioactive conjugated linoleic acid (CLA) from linoleic acid (LA), this being associated with a detoxifying mechanism. Primers employed in genotypic selection are generally species-specific. Therefore, this work aimed to identify CLA producers by previously screening genes encoding enzymes involved in LA isomerization with primers designed based on conserved moti...
Role of bioactive lipids in obesity
Salsinha, Ana Sofia; Rodríguez-Alcalá, Luís Miguel; Pimentel, Lígia Leão; Pintado, ManuelaObesity continues to be one of the major global challenges in the present century and its incidence nearly tripled between 1975 and 2016. It is estimated that obesity rates are going to increase further by 2030. The available drugs for obesity have not achieved the required level of clinical effectiveness and have been associated with severe health side effects. Diet has been widely recognized as playing a cent...
Microbiological in vivo production of CLNA as a tool in the regulation of host ...
Pimentel, Lígia Leão; Fontes, Ana Luiza; Salsinha, Ana Sofia; Cardoso, Beatriz Batista; Gomes, Ana Maria; Rodríguez-Alcalá, Luís MiguelMetabolic disorders associated with dietary patterns have become a social and economic problem. Obesity is indeed considered a central feature that increases the risks associated with a vast array of diseases (insulin resistance, type 2 diabetes, fatty liver disease, atherosclerosis, hypertension, stroke, cancer, and asthma), with significant morbidity and mortality. Although lipids may be involved in the devel...