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Cardiovascular and cerebrovascular risk markers in Parkinson’s disease: results...
Alves, Mariana; Pita Lobo, Patrícia; Azevedo Kauppila, Linda; Rebordão, Leonor; Cruz, M. Manuela; Soares, Fátima; Cruz, João; Tornada, AnaBackground: The relationship between Parkinson's disease (PD) and cardiovascular and cerebrovascular disease is not yet well established. Recent data suggest an increased risk of myocardial infarction and stroke in PD patients. Therefore, we designed a study to assess surrogate markers of cardiovascular and cerebrovascular risk in PD. Methods: We conducted a case-control study comparing PD patients recruited fr...
A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian mult...
Simões, Rita Moiron; Castro Caldas, Ana; Grilo, Joana; Correia, Daisy; Guerreiro, Carla; Pita Lobo, Patrícia; Valadas, Anabela; Fabbri, MargueritaBackground: Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson's disease. No early imaging biomarkers currently differentiate these disorders. Methods: Simple visual imaging analysis of the substantia nigra and locus coeruleus in neuromelanin-sensitive magnetic resonance imaging and nigrosome 1 in susceptibility-weighted sequences was performed i...
Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-relate...
Correia Guedes, Leonor; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; Soares, TiagoSpecific T-weighted MRI sequences are able to detect SN neuromelanin (NM) signal changes and accurately discriminate Parkinson’s disease (PD) patients from controls. The study of NM-MRI in PD patients carrying a LRRK2 gene mutation (LRRK2-PD) could contribute to further uncover LRRK2-associated phenotype. Albeit considered to largely overlap idiopathic PD (iPD), differences have been described. Furthermore, the...
Quantitative analysis versus visual assessment of Neuromelanin MR Imaging for t...
Reimão, Sofia; Pita Lobo, Patrícia; Neutel, Dulce; Correia Guedes, Leonor; Coelho, Miguel; Rosa, Mário Miguel; Ferreira, Joana; Abreu, DaisyBackground: Specific MR sequences have been able to identify the loss of neuromelanin in the substantia nigra (SN) of early stage Parkinson's disease (PD) patients. Since this technique may have a significant impact in clinical patient management, easy and widely available imaging analysis is needed for routine use. Objective: In this study we compared a quantitative analysis with a visual assessment of SN neur...