24 documents found, page 1 of 3
Diagnostic accuracy of a SARS-CoV-2 rapid test and optimal time for seropositiv...
David,Caroline Nespolo de; Varela,Fernanda Hammes; Sartor,Ivaine Tais Sauthier; Polese-Bonatto,Márcia; Fernandes,Ingrid RodriguesPoint-of-care serological tests for SARS-CoV-2 have been used for COVID-19 diagnosis. However, their accuracy over time regarding the onset of symptoms is not fully understood. We aimed to assess the accuracy of a point-of-care lateral flow immunoassay (LFI). Subjects, aged over 18 years, presenting clinical symptoms suggestive of acute SARS-CoV-2 infection were tested once by both nasopharyngeal and oropharyng...
High-resolution CT pulmonary findings in children with severe asthma
Silva,Thiago Krieger Bento da; Zanon,Matheus; Altmayer,Stephan; Pacini,Gabriel Sartori; Watte,Guilherme; Stein,Renato; Pitrez,Paulo MárcioAbstract Objective: To compare quantitative CT parameters between children with severe asthma and healthy subjects, correlating to their clinical features. Methods: We retrospectively analyzed CT data from 19 school-aged children (5-17 years) with severe asthma and 19 control school-aged children with pectus excavatum. The following CT parameters were evaluated: total lung volume (TLV), mean lung density (MLD),...
Association between interleukin-10 polymorphisms and CD4+CD25+FOXP3+ T cells in...
Mocellin,Magáli; Leitão,Lidiane Alves de Azeredo; Araújo,Patrícia Dias de; Jones,Marcus Herbert; Stein,Renato Tetelbom; Pitrez,Paulo MárcioAbstract Objective: The aim of this study was to evaluate the association between possible functional interleukin-10 (IL-10) polymorphisms, IL-10 expression and regulatory T cells (Tregs) frequency, and/or asthma severity in a sample of children and adolescents. Methods: This is a nested case-control genetic association study. The study sample consisted of children and adolescents aged 8–14 from public schools....
Qualidade de vida e desfechos em longo prazo após hospitalização por COVID-19: ...
Rosa,Regis Goulart; Robinson,Caroline Cabral; Veiga,Viviane Cordeiro; Cavalcanti,Alexandre Biasi; Azevedo,Luciano César Pontes deRESUMO Introdução: Os efeitos provocados pela COVID-19 em longo prazo são desconhecidos. O presente estudo tem como objetivo avaliar os fatores associados com a qualidade de vida relacionada à saúde e os desfechos em longo prazo em sobreviventes à hospitalização por COVID-19 no Brasil. Métodos: Este será um estudo multicêntrico de coorte prospectivo, aninhado em cinco ensaios clínicos randomizados desenhados pa...
2021 Brazilian Thoracic Association recommendations for the management of sever...
Carvalho-Pinto,Regina Maria de; Cançado,José Eduardo Delfini; Pizzichini,Marcia Margaret Menezes; Fiterman,Jussara; Rubin,Adalberto SperbABSTRACT Advances in the understanding that severe asthma is a complex and heterogeneous disease and in the knowledge of the pathophysiology of asthma, with the identification of different phenotypes and endotypes, have allowed new approaches for the diagnosis and characterization of the disease and have resulted in relevant changes in pharmacological management. In this context, the definition of severe asthma...
Características clínicas e preditores de ventilação mecânica em pacientes com C...
Bastos,Gisele Alsina Nader; Azambuja,Aline Zimmermann de; Polanczyk,Carisi Anne; Gräf,Débora Dalmas; Zorzo,Isabelle WeschenfelderRESUMO Objetivo: Descrever as características clínicas e os preditores de ventilação mecânica em pacientes adultos internados com COVID-19. Métodos: Conduziu-se um estudo de coorte retrospectiva com inclusão de pacientes hospitalizados entre 17 de março e 3 de maio de 2020, que tiveram o diagnóstico de infecção pelo SARS-CoV-2. As características clínicas e demográficas foram extraídas de registros em prontuári...
Effect of physical activity on asthma control in schoolchildren
Santos,Ana Paula dos; Strassburger,Márcio Júnior; Roncada,Cristian; Stein,Renato Tetelbom; Pitrez,Paulo Márcio; Strassburger,Simone ZeniABSTRACT Objective To investigate the effect of levels of physical activity on asthma control in children. Methods A cross-sectional study, including public school students aged 8 to 12 years, of both sexes, with asthma, from a capital and a medium-sized cities in Southern Brazil. At home, the students answered the questionnaire on levels of physical activity and disease control. Results A total of 482 schoolch...
OM-85 BV for primary prevention of recurrent airway infections: a pilot randomi...
Souza,Fátima Cleonice de; Mocellin,Magáli; Ongaratto,Renata; Leitão,Lidiane Alves de Azeredo; Friedrich,Frederico Orlando; Silveira,Victória d’AABSTRACT Objective To compare the frequency of respiratory tract infections in children treated with OM-85 BV and placebo during the 3-month therapy period, and observation for a further 3 months after treatment. Methods A randomized, double-blind, placebo-controlled trial was conducted with 54 children (6 months to 5 years old) with no past history of recurrent respiratory infections attending daycare center. ...
2020 Brazilian Thoracic Association recommendations for the management of asthma
Pizzichini,Marcia Margaret Menezes; Carvalho-Pinto,Regina Maria de; Cançado,José Eduardo Delfini; Rubin,,Adalberto Sperb; Cerci Neto,AlcindoABSTRACT The pharmacological management of asthma has changed considerably in recent decades, as it has come to be understood that it is a complex, heterogeneous disease with different phenotypes and endotypes. It is now clear that the goal of asthma treatment should be to achieve and maintain control of the disease, as well as to minimize the risks (of exacerbations, disease instability, accelerated loss of lu...
A azitromicina administrada para bronquiolite aguda pode ter um efeito de prote...
Luisi,Fernanda; Roza,Clarissa Aires; Silveira,Victória d’Azevedo; Machado,Camila Correia; Rosa,Katiana Murieli da; Pitrez,Paulo MárcioRESUMO Objetivo Uma proporção significativa de lactentes desenvolve sibilância recorrente após um evento de bronquiolite aguda (BA). Estudos recentes demonstraram proteção para sibilância recorrente e menor morbidade respiratória em lactentes tratados com azitromicina durante uma crise de sibilância. O objetivo do presente estudo foi testar a hipótese de que a administração de azitromicina durante um evento BA ...