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Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection F...
Butt, Jawad H.; Henderson, Alasdair D.; Jhund, Pardeep S.; Claggett, Brian L.; Desai, Akshay S.; Lay-Flurrie, James; Viswanathan, PrabhakarPublisher Copyright: © 2025 The Authors; Background: Obesity is associated with excessive adipocyte-derived aldosterone secretion, independent of the classical renin-angiotensin-aldosterone cascade, and mineralocorticoid receptor antagonists may be more effective in patients with heart failure (HF) and obesity. Objectives: This study sought to examine the effects of the nonsteroidal mineralocorticoid receptor a...
Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved...
Chimura, Misato; Wang, Xiaowen; Jhund, Pardeep S.; Henderson, Alasdair D.; Claggett, Brian L.; Desai, Akshay S.; Fonseca, Cândida; Goncalvesova, EvaPublisher Copyright: Copyright © 2024 Chimura M et al.; Importance: Sex is associated with the clinical presentation, outcomes, and response to treatment in patients with heart failure (HF). However, little is known about the safety and efficacy of treatment with finerenone according to sex. Objective: To estimate the efficacy and safety of finerenone compared with placebo in both women and men. Design, Setting...
Finerenone cardiovascular and kidney outcomes by age and sex
Bansal, Shweta; Canziani, Maria E.F.; Birne, Rita; Anker, Stefan D.; Bakris, George L.; Filippatos, Gerasimos; Rossing, Peter; Ruilope, Luis M.Objectives This study aimed to evaluate the efficacy and safety of finerenone, a selective, non-steroidal mineralocorticoid receptor antagonist, on cardiovascular and kidney outcomes by age and/or sex. Design FIDELITY post hoc analysis; median follow-up of 3 years. Setting FIDELITY: a prespecified analysis of the FIDELIO-DKD and FIGARO-DKD trials. Participants Adults with type 2 diabetes and chronic kidney dise...
Baseline characteristics of patients with heart failure with mildly reduced or ...
Solomon, Scott D.; Ostrominski, John W.; Vaduganathan, Muthiah; Claggett, Brian; Jhund, Pardeep S.; Desai, Akshay S.; Lam, Carolyn S.P.; Pitt, BertramPublisher Copyright: © 2024 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.; Aims: To describe the baseline characteristics of participants in the FINEARTS-HF trial, contextualized with prior trials including patients with heart failure (HF) with mildly reduced and preserved ejection fraction (HFmrEF/HFpEF). The FINEARTS-HF trial is ...