8 documents found, page 1 of 1
Analysis of the self-medication profile in COVID-19 pandemic in Brazil
Pitta, Marina Galdino da Rocha; Lima, Luzilene Pereira de; Carvalho, Jordy Silva de; Teixeira, Diego Rodrigues Cravo; Nunes, Tiago Rafael de SousaThis manuscript aims to analyze the brazilian profile of self-medication during the COVID-19 pandemic and to collect sociodemographic informations related to the self-medication. Therefore, it was necessary to investigate the concept of what participants understand about self-medication, in addition to examining what type of medication is used by those who self-medicated and it’s side effects. A research was ca...
Ability of two new thiazolidinediones to downregulate proinflammatory cytokines...
Rêgo, Moacyr Jesus Barreto de Melo; Azoubel-Antunes, Adriana; Bezerra, Mariana Brayner-Cavalcanti Freire; Pereira, Michelly CristinyAllergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, particularly that involving peroxisome proliferator-activated receptors (PPARs). In response, two new thiazolidinedione derivatives—namely, LPSF–GQ-147 and LPSF–CR-35...
GQ-16, a TZD-derived partial PPARγ agonist, induces the expression of thermogen...
Coelho, Michella S.; Lima, Caroline Lourenço de; Royer, Carine; Silva, Janaina Barbosa da; Oliveira, Fernanda C. B.; Christ, Camila G.Background Beige adipocytes comprise a unique thermogenic cell type in the white adipose tissue (WAT) of rodents and humans, and play a critical role in energy homeostasis. In this scenario, recruitment of beige cells has been an important focus of interest for the development of novel therapeutic strategies to treat obesity. PPARγ activation by full agonists (thiazolidinediones, TZDs) drives the appearance of ...
Synthesis and biological evaluation of novel imidazolidine derivatives as candi...
Matos-Rocha, Thiago José; Lima, Maria do Carmo Alves de; Silva, Anekécia Lauro da; Oliveira, Jamerson Ferreira de; Gouveia, Allana Lemos AndradeIntroduction: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives. Material and methods: We synthesized two novel imidazolidine deriv...
Improved nonclinical pharmacokinetics and biodistribution of a new PPAR pan-ago...
Garcia, Giani Martins; Oliveira, Liliam Teixeira; Pitta, Ivan da Rocha; Lima, Maria do Carmo Alves de; Vilela, José Mário CarneiroWereport the in vitro release profile and comparative pharmacokinetics and biodistribution of a newperoxisome proliferator-activated receptor-γ agonist and cyclooxygenase inhibitor (Lyso-7) free or associated to poly(D,Llactic acid) nanocapsules (NC) after intravenous administration in mice. Lyso-7 pertains to the class of insulinsensitizing agents that shows potential beneficial effects in diabetes therapy. Mo...
On the application of knoevenagel condensation for the synthesis of benzylidene...
Souza, Ana Maria Alves de; Guarda, Vera Lúcia de Miranda; Leite, Lucia Fernanda Cavalcanti da Costa; Barbosa Filho, José MariaThe synthesis and physico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4Hbenzo[1,4]thiazin-3-ones and 6-benzoylamino or 6-nitro 2-benzylidene-4H-benzo[1,4]thiazin-3-ones are described. These benzylidene benzothiazine compounds were prepared by the Knoevenagel condensation with benzaldehydes. The configurations and conformations of benzylidene benzothiazine derivatives were ...
GQ-16, a novel peroxisome proliferator-activated receptor (PPAR ) ligand, promo...
Amato, Angélica Amorim; Rajagopalan, Senapathy; Lin, Jean Z.; Carvalho, Bruno de Melo; Figueira, Ana Carolina Migliorini; Lu, Jenny; Ayers, Stephen D.ABSTRACT; Background: PPAR agonists improve insulin sensitivity but also evoke weight gain. Results: GQ-16 is a PPAR partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin sensitivity in diabetic mice in the absence of weight gain. Conclusion: The unique binding mode of GQ-16 appears to be responsible for the compound’s advantageous pharmacological profile. Significance: Similar compo...
Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythemat...
Silva, Juliana Cruz da; Mariz, Henrique Ataide; Rocha Júnior, Laurindo Ferreira da; Oliveira, Priscilla Stela Santana de; Dantas, Andrea TavaresOBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. The purpose of this study was to evaluate the immunomodulatory activity of hydroxychloroquine in T helper 17 (Th17) cytokines in hea...