2 documents found, page 1 of 1
Significance of glycolytic metabolism-related protein expression in colorectal ...
Martins, Sandra; Amorim, Ricardo Luís Agra de; Pereira, Marta Sofia Carvalho Ribeiro Viana; Pinheiro, Céline; Silva, Patrícia; Couto, Carla; Alves, SaraBackground: Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs). The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cas...
The structure-function relationship of HIV-1 Vif protein and its regulation
Couto, CarlaOne of the critical determinants of HIV-1 infectivity is the capacity of the virus to infect new cells. The viral Vif protein is one of the critical factors involved in the increase infectivity of the virus. Vif protein is required for HIV to replicate in some human cell types (termed non-permissive' cells), but not others ( permissive' cells). The reason for this is the expression, in non-permissive cells, of ...