2 documents found, page 1 of 1
Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits a...
Lopes, Sofia Oliveira; Lopes, André Teixeira; Pinto, Vítor Manuel Silva; Guimarães, Marco Rafael; Sardinha, Vanessa Alexandra Morais; Silva, Sara DuarteDementia is the cardinal feature of Alzheimer's disease (AD), yet the clinical symptoms of this disorder also include a marked loss of motor function. Tau abnormal hyperphosphorylation and malfunction are well-established key events in AD neuropathology but the impact of the loss of normal Tau function in neuronal degeneration and subsequent behavioral deficits is still debated. While Tau reduction has been inc...
Subregion-dependent specificities of the hippocampal formation to the acute app...
Pizarro, João Pedro RodriguesAlzheimer’s disease (AD) is a neurodegenerative disorder and the main cause of dementia worldwide. It is characterized by the presence of extracellular plaques of Amyloid-β (Aβ) and intracellular neurofibrillary tangles of Tau protein. Since the discovery of the mutations leading to the familial form of AD, and their relationship with the overproduction of Aβ, the amyloidogenic hypothesis has been the most acce...