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Gestational age at birth and body size from infancy through adolescence: An ind...

Vinther, JL; Cadman, T; Avraam, D; Ekstrom, CT; Sorensen, TIA; Elhakeem, A; Santos, AC; de Moira, AP; Heude, B; Iñiguez, C; Pizzi, C; Simons, E

Background Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. ...


Exposure to natural environments during pregnancy and birth outcomes in 11 euro...

Torres Toda, M; Avraam, D; James Cadman, T; Fossati, S; de Castro, M; Dedele, A; Donovan, G; Elhakeem, A; Estarlich, M; Fernandes, A; Gonçalves, R

Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, par...


Early-life respiratory tract infections and the risk of school-age lower lung f...

van Meel, ER; Mensink-Bout, SM; den Dekker, HT; Ahluwalia, TS; Annesi-Maesano, I; Arshad, SH; Baïz, N; Barros, H; von Berg, A; Bisgaard, H

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child ...


Changes in parental smoking during pregnancy and risks of adverse birth outcome...

Philips, EM; Santos, S; Trasande, L; Aurrekoetxea, JJ; Barros, H; von Berg, A; Bergström, A; Bird, PK; Brescianini, S; Ní Chaoimh, C; Charles, MA

Background. Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, spec...


Maternal body mass index, gestational weight gain, and the risk of overweight a...

Voerman, E; Santos, S; Patro Golab, B; Amiano, P; Ballester, F; Barros, H; Bergström, A; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP

Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gai...


Impact of maternal body mass index and gestational weight gain on pregnancy com...

Santos, S; Voerman, E; Amiano, P; Barros, H; Beilin, LJ; Bergström, A; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP; Corpeleijn, E; Costa, O

Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gai...


Gestational weight gain charts for different body mass index groups for women i...

Santos, S; Eekhout, I; Voerman, E; Gaillard, R; Barros, H; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP; Corpeleijn, E; Costet, N; Crozier, S

BackgroundGestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, n...


Fish and seafood consumption during pregnancy and the risk of asthma and allerg...

Stratakis, N; Roumeliotaki, T; Oken, E; Ballester, F; Barros, H; Basterrechea, M; Cordier, S; de Groot, R; den Dekker, HT; Duijts, L; Eggesbø, M

Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis...


Fish Intake in Pregnancy and Child Growth A Pooled Analysis of 15 European and ...

Stratakis, N; Roumeliotaki, T; Oken, E; Barros, H; Basterrechea, M; Charles, MA; Eggesbo, M; Forastiere, F; Gaillard, R; Gehring, U; Govarts, E

IMPORTANCE: Maternal fish intake in pregnancy has been shown to influence fetal growth. The extent to which fish intake affects childhood growth and obesity remains unclear. OBJECTIVE:To examine whether fish intake in pregnancy is associated with offspring growth and the risk of childhood overweight and obesity. DESIGN, SETTING, AND PARTICIPANTS:Multicenter, population-based birth cohort study of singleton deli...


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