37 documents found, page 1 of 4
Peptide conjugates for the topical treatment of infected wounds
Gomes, Ana; Fernandes, Iva; Bessa, Lucinda; Ferreira, Mariana; Maciel, Joana; Plácido, Alexandra; Teixeira, Cátia; Leal, Ermelindo; Ferraz, RicardoDue to widespread multidrug-resistant (MDR) microbes, efficient treatments for infected wounds are being exhausted.1 The symptoms of wound infection are consistent with local polymicrobial biofilms, which are difficult to eliminate and delay the healing process. The current standard of care requires oral antibiotics and other measures, often complex and distressing (e.g., amputations). A perfect treatment shoul...
The peptide secreted at the water to land transition in a model amphibian has a...
Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Silva-Carvalho, Amandda É.; Cabral, Wanessa F.Made available in DSpace on 2022-04-29T08:36:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the develo...
The peptide secreted at the water to land transition in a model amphibian has a...
Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Carvalho, Amandda É. Silva; Cabral, Wanessa F.In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the developmental stage that precedes the onset of terrestrial behaviour. De novo peptide and cDNA sequencing revealed t...
Neuroprotective effects on microglia and insights into the structure–activity r...
Plácido, Alexandra; Amaral, Constança Pais Do; Teixeira, Cátia; Nogueira, Ariane; Brango‐Vanegas, José; Alves Barbosa, Eder; C. Moreira, DanielTryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian's skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fract...
Neuroprotective effects on microglia and insights into the structure–activity r...
Plácido, Alexandra; Amaral, Constança do Pais do; Teixeira, Cátia; Nogueira, Ariane; Brango-Vanegas, José; Barbosa, Eder Alves; Moreira, Daniel C.Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian’s skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fract...
Acetylated cashew-gum-based silver nanoparticles for the development of latent ...
Brandão, Marcela de S.; Jesus, Joilson R.; de Araújo, Alyne R.; de Carvalho, Juarez G.; Peixoto, Miguel; Plácido, Alexandra; Eaton, PeterMade available in DSpace on 2021-06-25T10:44:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Universidade Estadual Paulista; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fingerprints have been used in forensic investigations as a powerful tool for human identification. However, it is desirable to find new sustainable sources and synthesis for fingerprint developers, in ...
Mechanistic insights into the leishmanicidal and bactericidal activities of Bat...
Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria SilvaSnake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed f...
The antioxidant peptide salamandrin-i: First bioactive peptide identified from ...
Plácido, Alexandra; Bueno, João; Barbosa, Eder A.; Moreira, Daniel C.; Dias, Jhones Do Nascimento; Cabral, Wanessa Felix; Albuquerque, PatríciaMade available in DSpace on 2020-12-12T02:01:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01; Universidade Estadual Paulista; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação para a Ciência e a Tecnologia; Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and wat...
Novel ocellatin peptides mitigate LPS-induced ROS formation and NF-kB activatio...
Sousa, Nayara A.; Oliveira, Guilherme A. L.; de Oliveira, Ana Patrícia; Lopes, André Luís F.; Iles, Bruno; Nogueira, Kerolayne M.; Araújo, Thiago S. L.Cutaneous secretions of amphibians have bioactive compounds, such as peptides, with potential for biotechnological applications. Therefore, this study aimed to determine the primary structure and investigate peptides obtained from the cutaneous secretions of the amphibian, Leptodactylus vastus, as a source of bioactive molecules. The peptides obtained possessed the amino acid sequences, GVVDILKGAAKDLAGH and GVV...
Antibacterial application of natural and carboxymethylated cashew gum-based sil...
Araruna, Felipe Bastos; de Oliveira, Taiane Maria; Quelemes, Patrick Veras; de Araújo Nobre, Alyne Rodrigues; Plácido, AlexandraThis study presents a green synthesis route to silver nanoparticles (AgNPs) stabilized with cashew gum (CG) or carboxymethylated cashew gum (CCG) using microwave-assisted synthesis and evaluates their antibacterial activity. The antimicrobial activity was measured by determining the minimum inhibitory concentration (MIC) with Staphylococcus aureus and Escherichia coli. In both cases of the presence of CG and CC...