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Management of the Adverse Effects of Immune Checkpoint Inhibitors
Morgado, Manuel; Plácido, Ana; Morgado, Sandra; Roque, FátimaBy increasing the activity of the immune system, immune checkpoint inhibitors (ICPI) can have adverse inflammatory effects, which are referred to as immune-related adverse effects (irAEs). In this review, we present the recommendations for the appropriate identification and treatment of irAEs associated with ICPI to increase the safety and effectiveness of therapy with these immuno-oncological drugs. Several gu...
Arbutus unedo L.: From traditional medicine to potential uses in modern pharmac...
Morgado, Sandra; Morgado, Manuel; Plácido, Ana; Roque, Fátima; Duarte, Ana PaulaEthnopharmacological relevance: Arbutus unedo L., the strawberry tree (Ericaceae family) is of increasing interest because of its common traditional, industrial, chemical and pharmaceutical uses. The plant is a typical evergreen plant of the Mediterranean basin, as well as of other regions with hot summers and mild rainy winters. This review covers the studies relevant to Arbutus unedo L. utilization in the cur...
Voices of Polymedicated Older Patients: A Focus Group Approach
Plácido, Ana; Herdeiro, Maria; Simões, João; Amaral, Odete; Figueiras, Ana; Roque, FátimaPolypharmacy in older adults is frequently associated with incorrect management of medicines, which causes drug-related problems and, subsequently, poor health outcomes. Understanding why older adults incorrectly manage their medicines is fundamental to health outcomes, however, it is an issue that remains poorly explored. The aim of this study is to examine older people's perceptions, attitudes, beliefs, and c...
Profile of Prescription Medication in an Internal Medicine Ward
Perpétuo, Carla; Plácido, Ana; Aperta, Jorge; Herdeiro, Maria; Roque, FátimaAging-related loss of resilience associated with the lack of evidence regarding the therapeutic efficacy of medicines can prompt a lack of efficacy of treatments and multiple prescriptions. This work aims to characterize the medication profile of Portuguese older adult inpatients and explore the relationship between hospitalization days and the consumption of medicines. A retrospective data analysis study in ol...
Drug-related Problems in Home-dwelling Older Adults: A Systematic Review
Plácido, Ana; Herdeiro, Maria; Morgado, Manuel; Figueiras, Adolfo; Roque, FátimaPurpose: The complex combination of medicines associated with age-related physiological alterations leads older adults to experience drug-related problems (DRPs). The goal of this study was to review the frequency and type of DRPs and DRP risk factors in home-dwelling older adults. Methods: A MEDLINE PubMed and EMBASE scientific databases search was performed. Articles published from January 2000 through Decemb...
How Portuguese Health Entities Used Social Media to Face the Public Health Emer...
Azevedo, Daniela; Plácido, Ana; Herdeiro, Maria; Roque, Fátima; Roque, VítorBackground: During the COVID-19 pandemic, social media became an important and easily accessible source of information to keep the population informed. In this study, we explored how Portuguese health entities used social media during the public health emergency caused by COVID-19 disease. Methods: A retrospective study on Portuguese public health entities' communication with the public using social media platf...
Early Real-World Data to Assess Benefits and Risks of COVID-19 Vaccines: A Syst...
Ribeiro, Tatiane; Roque, Fátima; Ida, Fidelia; Plácido, Ana; Vu, Mai; Hernández-Muñoz, José; Herdeiro, MariaSince the authorization of the first COVID-19 vaccines in December 2020, multiple studies using real-world data (RWD) have been published to assess their effectiveness/safety profile. This systematic review aimed to characterize the methods and outcomes of studies using RWD for assessment of COVID-19 vaccines, four months after vaccine approval. MEDLINE and EMBASE were searched to identify published studies unt...
Descriptive Analysis of Adverse Drug Reactions Reports of the Most Consumed Ant...
Ferreira, Joana; Plácido, Ana; Afreixo, Vera; Ribeiro-Vaz, Inês; Roque, Fátima; Herdeiro, MariaAdverse drug reactions (ADR) significantly impact mortality and morbidity and lead to high healthcare costs. Reporting ADR to regulatory authorities allows for monitoring the safety and efficacy profile of medicines on the market and for assessing the benefit-risk ratio. This retrospective study aims to characterize the ADR profile of the most consumed antibiotics in Portugal that are prescribed for upper airwa...
Potentially Inappropriate Medication Prescribing in Older Adults According to E...
Rodrigues, Daniela; Plácido, Ana; Tavares, Ana; Azevedo, Daniela; Mateos-Campos, Ramona; Figueiras, Adolfo; Herdeiro, Maria; Roque, FátimaBackground: Portugal has among the highest rates of dependency among older adults in Europe. Older adults with aging-related comorbidities are prone to the use of potentially inappropriate medication (PIM). Objective: The aim of this study was to analyze PIM prescriptions in older Portuguese adults, as well as the change rate of PIM prescriptions over time, and assess the geographical variability between the di...
Assessment of Potentially Inappropriate Medications Using the EU (7)-PIM List, ...
Plácido, Ana; Aguiar, Ana; Piñeiro-Lamas, María; Varallo, Fabiana; Figueiras, Adolfo; Herdeiro, Maria; Roque, FátimaAbstract: Prescription of potentially inappropriate medication (PIM) in older adults is associated with poor clinical outcomes. The EU (7)-PIM list was created for the European market to improve pharmacotherapy in older adults. Purpose: This work aims to characterize the medication profile and assess the presence of PIM, using the EU (7)-PIM list in older adults' residents at nursing homes. Methods: Retrospecti...