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Loneliness and Frailty Among Middle-Aged and Aging Sexual Minority Men Living W...

Meireles, P; Ware, D; Henriques, A; Nieves-Lugo, K; Stosor, V; Brennan-Ing, M; Meanley, S; Haberlen, S; Okafor, CN; Shoptaw, S; Friedman, MR; Plankey, M

Background and Objectives Loneliness is associated with frailty among older adults (60+), and there is evidence suggesting that this association may be bidirectional. However, there is limited evidence of this relationship over time among middle-aged and aging sexual minority men. We explored the bidirectional relationship between loneliness and frailty over 2 years among sexual minority men living with or with...


Transitions Between Preexposure Prophylaxis Eligibility States and HIV Infectio...

Meireles, P; Moreira, C; Rocha, M; Plankey, M; Barros, H

We aimed to describe transitions between preexposure prophylaxis (PrEP) eligibility and human immunodeficiency virus (HIV) infection among HIV-negative men who have sex with men (MSM). We used data from 1,885 MSM, who had not used PrEP, enrolled in the Lisbon Cohort of MSM, with at least 2 consecutive measurements of PrEP eligibility from 2014–2020. A time-homogeneous Markov multistate model was applied to desc...


Provision of Preexposure Prophylaxis at the Portuguese National Health Service ...

Meireles, P; Fernandes, F; Rocha, M; Plankey, M; Barros, H

We aimed to study the uptake of preexposure prophylaxis (PrEP) before and after its implementation in the Portuguese National Health Service (PNHS) among men who have sex with men (MSM). We studied 6164 participants in the Lisbon Cohort of MSM who participated between March 2014 and July 2019. 198 participants (3.2%) reported having recently used PrEP. Approximately one-third started PrEP after its implementati...


Different guidelines for pre-exposure prophylaxis (PrEP) eligibility estimate H...

Meireles, P; Plankey, M; Rocha, M; Brito, J; Mendão, L; Barros, H

Introduction. Guidelines for pre-exposure prophylaxis (PrEP) provide criteria to identify individuals at higher risk of HIV infection. We compared the ability to predict HIV seroconversion of four guidelines: the World Health Organization (WHO), the United States Public Health Service and Centers for Disease Control and Prevention (US CDC), the European AIDS Clinical Society (EACS) and the Portuguese National H...


Eligibility for Pre-exposure Prophylaxis According to Different Guidelines in a...

Meireles, P; Plankey, M; Rocha, M; Rojas, J; Brito, J; Barros, H

Objectives. Defining eligibility for preexposure prophylaxis (PrEP) is key to measuring the degree of PrEP implementation. While the clinical exclusion criteria are identical across different guidelines, definitions of substantial HIV risk are not. In this study, we aimed to estimate the proportion of men who have sex with men (MSM) being tested at a community-based voluntary human immunodeficiency virus (HIV) ...


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