9 documents found, page 1 of 1
Pharmacovigilance in Portugal: Activity of the Central Pharmacovigilance Unit
Batel-Marques, Francisco; Mendes, Diogo; Alves, Carlos; Penedones, Ana; Dias, Patricia; Martins, Angelina; Santiago, Luiz Miguel; Fontes-Ribeiro, CarlosIntroduction: The aim of this study was to characterize the spontaneous reports of adverse events that were received by the Central Portugal Regional Pharmacovigilance Unit.Material and Methods: Spontaneous reports received between 01/2001 and 12/2013 were considered. The annual reporting ratios were estimated. The cases were characterized according to their seriousness, previous description, causality assessme...
Neurotoxicity of heroin-cocaine combinations in rat cortical neurons
Cunha-Oliveira, Teresa; Rego, A. Cristina; Garrido, Jorge; Borges, Fernanda; Macedo, Tice; Oliveira, Catarina R.Cocaine and heroin are frequently co-abused by humans, in a combination known as speedball. Recently, chemical interactions between heroin (Her) or its metabolite morphine (Mor) and cocaine (Coc) were described, resulting in the formation of strong adducts. In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, ...
Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity ...
Domingues, António; Cunha-Oliveira, Teresa; Laço, Mário L. N.; Macedo, Tice; Oliveira, Catarina R.; Rego, A. CristinaRepeated use of drugs of abuse, namely opiates, has been shown to affect glutamate-releasing neurons. Moreover, blockade of N-methyl-D-aspartate (NMDA) receptors (NMDAR) prevents cell death by apoptosis induced by morphine, a heroin metabolite. Thus, in this article we investigated the involvement of different NMDAR subunits in heroin cytotoxicity. Human embryonic kidney (HEK293)cells, which do not express nati...
Controvérsias na Anticoagulação Oral: Continuar ou Interromper os Anticoagulant...
António, Natália; Castro, Graça; Ramos, Domingo; Machado, António; Gonçalves, Lino; Macedo, Tice; Providência, Luís A.A abordagem dos doentes cronicamente anticoagulados com necessidade de intervenções estomatológicas continua a suscitar grande controvérsia. O aumento do risco hemorrágico associado aos procedimentos estomatológicos sob anticoagulação oral deve ser pesado relativamente ao risco trombótico acrescido causado pela interrupção da terapêutica antitrombótica. Em cirurgia oral minor, a mortalidade e morbilidade é supe...
Unaltered hepatic oxidative phosphorylation and mitochondrial permeability tran...
Moreno, António J.; Oliveira, Paulo J.; Nova, Carlos D.; Álvaro, Ana R.; Moreira, Renata A.; Santos, Sandra M. D.; Macedo, TiceNonsteroidal anti-inflammatory drugs have been associated with hepatotoxicity in susceptible patients. One such example is nimesulide, a preferential cyclooxygenase 2-inhibitor, widely used for the treatment of inflammation and pain. It was suggested that nimesulide could exert its hepatotoxicity by altering hepatic mitochondrial function, which was demonstrated in vitro. The objective of this study was to veri...
Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical n...
Cunha-Oliveira, Teresa; Rego, A. Cristina; Garrido, Jorge; Borges, Fernanda; Macedo, Tice; Oliveira, Catarina ResendeCortical function has been suggested to be highly compromised by repeated heroin self-administration. We have previously shown that street heroin induces apoptosis in neuronal-like PC12 cells. Thus, we analysed the apoptotic pathways involved in street heroin neurotoxicity using primary cultures of rat cortical neurons. Our street heroin sample was shown to be mainly composed by heroin, 6-monoacetylmorphine and...
Spectroscopic and electrochemical studies of cocaine–opioid interactions
Garrido, Jorge; Marques, M. Paula M.; Silva, Artur; Macedo, Tice; Brett, Ana Oliveira; Borges, FernandaAbstract The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine–opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug–drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine–morphine mi...
Differential cytotoxic responses of PC12 cells chronically exposed to psychosti...
Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina ResendeRepeated abuse of stimulant drugs, cocaine and amphetamine, is associated with extraneuronal dopamine accumulation in specific brain areas. Dopamine may be cytotoxic through the generation of reactive oxygen species, namely hydrogen peroxide (H2O2), resulting from dopamine oxidative metabolism. In this work, we studied the cytotoxicity in PC12 cells (a dopaminergic neuronal model) chronically and/or acutely exp...
Relative bioavailability and bioquivalence of three different oral formulations...
Nunes, Teresa; Falcão, Amílcar; Almeida, Luís; Lima, Ricardo; Tavares, Susana; Neta, Carla; Fontes-Ribeiro, Carlos; Macedo, TiceAES Proceedings of the Annual Meeting of the American Epilepsy Society; To investigate the bioavailability and bioequivalence of three formulations of eslicarbazepine acetate: 50 mg/mL oral suspension (Test 1), 200 mg tablets (Test 2) and 800 mg tablets (Reference)