6 documents found, page 1 of 1
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Ade...
Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; Gonçalves, NélioIncreased ATP release and its extracellular catabolism through CD73 (ecto-5'-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood and memory dysfunction caused by repeated stress, but it is unknown if increased ATP release coupled to CD73-mediated formation of extracellular adenosine is responsible for A2AR overactivatio...
Increased ATP release and CD73-mediated adenosine A2A receptor activation media...
Augusto, Elisabete de Oliveira; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, MarcoExtracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR). Convulsive activity leads to increased ATP release, with the resulting morphological alterations being eliminated by A2AR blockade. However, it is not known i...
Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflamm...
Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana R.; Pochmann, Daniela; Machado, Nuno J.; Tomé, Ângelo R.; Agostinho, PaulaDepressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and adenosine A2A receptors (A2AR) antagonists attenuate behavioral modifications upon exposure to repeated stress. Since it is unknown if these two purinergic modulation systems work independently, we now investigated a putative interplay betwee...
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 rec...
Simões, Ana P.; Silva, Carla G.; Marques, Joana M.; Pochmann, Daniela; Porciúncula, Lisiane O.; Ferreira, Sofia; Oses, Jean P.; Beleza, Rui de O.Despite the characteristic etiologies and phenotypes, different brain disorders rely on common pathogenic events. Glutamate-induced neurotoxicity is a pathogenic event shared by different brain disorders. Another event occurring in different brain pathological conditions is the increase of the extracellular ATP levels, which is now recognized as a danger and harmful signal in the brain, as heralded by the abili...
Caffeine reverts memory but not mood impairment in a depression-prone mouse str...
Machado, Nuno J.; Simoes, Ana Patricia; Silva, Henrique B.; Ardais, Ana Paula; Kaster, Manuella P.; Garcao, Pedro; Rodrigues, Diana I.Caffeine prophylactically prevents mood and memory impairments through adenosine A(2A) receptor (A(2A)R) antagonism. A(2A)R antagonists also therapeutically revert mood and memory impairments, but it is not known if caffeine is also therapeutically or only prophylactically effective. Since depression is accompanied by mood and memory alterations, we now explored if chronic (4 weeks) caffeine consumption (0.3 g/...
Identificação bioquímica e molecular de nucleotidases em fração solúvel e micro...
Pochmann, DanielaOs nucleotídeos da adenina (ATP, ADP e AMP) e o nucleosídeo adenosina são importantes moléculas sinalizadoras que estão envolvidas nos mecanismos de crescimento e diferenciação celular, angiogênese, fluxo sanguíneo, condução e taxa cardíaca, e sensibilidade à estimulação adrenérgica no coração. Paralelamente a esses efeitos extracelulares, algumas evidências com fibras musculares permeabilizadas e vesículas de ...