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Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder

Gonçalves, ÓF; Soares, JM; Carvalho, S; Leite, J; Ganho-Ávila, A; Fernandes-Gonçalves, A; Pocinho, F; Carracedo, A; Sampaio, A

The objective of the present study was to research the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in the transition between a resting and a non-rest emotional condition. Twenty-seven participants, 15 diagnosed with OCD and 12 healthy controls (HC), underwent a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrasted with...

Date: 2017   |   Origin: Saúde - CUF

Imbalance in habitual versus goal directed neural systems during symptom provoc...

Banca, P; Voon, V; Vestergaard, MD; Philipiak, G; Almeida, I; Pocinho, F; Relvas, J; Castelo-Branco

Intrusive thoughts and compulsive urges to perform stereotyped behaviours are typical symptoms of obsessive-compulsive disorder. Emerging evidence suggests a cognitive bias towards habit formation at the expense of goal-directed performance in obsessive-compulsive disorder. In this study, we test this hypothesis using a novel individualized ecologically valid symptom provocation design: a live provocation funct...


Brain activation of the defensive and appetitive survival systems in obsessive ...

Gonçalves, OF; Soares, JM; Carvalho, S; Leite, J; Ganho, A; Fernandes-Gonçalves, A; Frank, B; Pocinho, F; Relvas, J; Carracedo, A; Sampaio, A

Several studies have shown that basic emotions are responsible for a significant enhancement of early visual processes and increased activation in visual processing brain regions. It may be possible that the cognitive uncertainty and repeated behavioral checking evident in Obsessive Compulsive Disorder (OCD) is due to the existence of abnormalities in basic survival circuits, particularly those associated with ...


Obsessive Compulsive Disorder as a functional interhemispheric imbalance at the...

Gonçalves, OF; Carvalho, S; Leite, J; Pocinho, F; Relvas, J; Fregni, F

Obsessive Compulsive Disorder (OCD) involves failures in two main inhibitory processes, namely cognitive (obsessions) and behavioral (compulsions). Recent research has supported two cortical-subcortical pathways on OCD pathogenesis: (a) the frontostriatal loop (dorsolateral-caudate-striatum-thalamus) responsible for impairments of behavioral inhibition; (b) the orbitofrontal loop (orbitofrontal, medial prefront...


Psicoterapia e Neurociências: o que muda no cérebro

Pocinho, F; Madeira, N; Marques, D; Bettencourt, D; Relvas, J


Perfectionism in obsessive-compulsive and eating disorders

Maia, BR; Soares, MJ; Gomes, A; Marques, M; Pereira, AT; Cabral, AS; Valente, J; Bos, SC; Pato, ML; Pocinho, F; Azevedo, MH; Macedo, A

OBJETIVO: Este estudo tem dois objetivos principais. Primeiro, avaliar as dimensões do perfeccionismo no transtorno obsessivo-compulsivo e nos transtornos alimentares em comparação com duas amostras controle: psiquiátrica (depressão/ansiedade) e não clínica. Segundo, avaliar se o perfeccionismo é um traço de personalidade especificamente relacionado com estas diferentes condições clínicas. MÉTODO: 39 pacientes ...



Perfeccionismo e perturbações do espectro obsessivo-compulsivo: resultados prel...

Maia, BR; Pereira, AT; Soares, MJ; Bos, SC; Cabral, AS; Valente, J; Macedo, A; Pocinho, F; Azevedo, MH



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