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Accumulation of organotins in seafood leads to reproductive tract abnormalities...

Podratz, Priscila Lang; Merlo, Eduardo; Sena, Gabriela C.; Morozesk, Mariana; Bonomo, Marina Marques; Matsumoto, Silvia T.; Costa, Mércia Barcellos da

Organotins (OTs) are environmental contaminants used as biocides in antifouling paints that have been shown to be endocrine disrupters. However, studies evaluating the effects of OTs ccumulated in seafood (LNI) on reproductive health are particularly sparse. This study demonstrates that LNI leads to impairment in the reproductive tract of female rats, as the estrous cycle development, as well as for ovary and u...

Date: 2022   |   Origin: Oasisbr

Tributyltin chloride leads to adiposity and impairs metabolic functions in the ...

Bertuloso, Bruno Duarte; Podratz, Priscila Lang; Merlo, Eduardo; Araújo, Julia Fernandez Puñal de; Lima, Leandro Ceotto Freitas

Tributyltin chloride (TBT) is an environmental contaminant used in antifouling paints of boats Endocrine disruptor effects of TBT are well established in animal models. However, the adverse effects on metabolism are less well understood. The toxicity of TBT in the white adipose tissue (WAT), liver and pancreas of female rats were assessed. Animals were divided into control and TBT (0.1 mg/kg/day) groups. TBT in...

Date: 2022   |   Origin: Oasisbr

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