33 documents found, page 1 of 4

Cerebral venous thrombosis as a first presentation of a high-risk acute myeloid...

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosome...

The decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. We discovered that human p11 is a critical factor for this decision. The HscA protein present on the conidial surface of the human-pathogenic fungus Aspergillus fumigatus anchors p11 on conidia-containing phagosomes ...

Genetic determinants of fungi-induced ROS production are associated with the ri...

Reactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic factors that regulate ROS production capacity in response to the two human fungal pathogens: Candida albicans and Aspergillus fumigatus. We investigated f...

Hematopoietic stem cell transplantation for neurological disorders: a focus on ...

Hematopoietic stem cells have been investigated and applied for the treatment of certain neurological disorders for a long time. Currently, their therapeutic potential is harnessed in autologous and allogeneic hematopoietic stem cell transplantation (HSCT). Autologous HSCT is helpful in immune-mediated neurological diseases such as Multiple Sclerosis. However, clinical benefits derive more from the immunosuppre...

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host di...

Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies. However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory complications can occur, among which chronic graft-versus-host disease (cGVHD) can be life-threatening. A classical therapeutic approach to the prevention and tr...

MAVS expression in alveolar macrophages is essential for host resistance agains...

Our recent data demonstrate a critical role of the RIG-I-like receptor family in regulating antifungal immunity against Aspergillus fumigatus in a murine model. However, the importance of this pathway in humans and the cell types that use this innate immune receptor family to detect A. fumigatus remain unresolved. In this study, using patients who underwent hematopoietic stem cell transplantation, we demonstrat...

Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and pr...

Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermined whether these are differentially regulated at the interindividual level. In this study, we identify a key role...

Serum amyloid P component is an essential element of resistance against Aspergi...

Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhan...

Suppression by allogeneic-specific regulatory T cells is dependent on the degre...

Regulatory T cell (Treg) infusion for graft-versus-host disease treatment has been increasingly investigated. However, polyclonal Treg may suppress the desired graft-versus-leukemia effect. Although allogeneic-specific (allo-specific) Treg may provide a more-targeted graft-versus-host disease treatment, there is the need to develop easily translatable expansion protocols and to better characterize their specifi...

Tumor lipomatoso intra-articular do joelho: Dois casos similares, mas diferentes

Embora os tumores lipomatosos sejam comuns, a ocorrência intra-articular é extremamente rara e escassamente descrita na literatura. Em relação a essas entidades raras, a maioria é benigna, tumores de crescimento progressivo e geralmente ocorrem no joelho, mas é crucial distinguir o menos frequente lipoma arborescens (LA) do lipoma sinovial mais raro, pois diferem na apresentação e na patogênese. A ressonância m...