10 documents found, page 1 of 1
Identification of novel candidate predisposing genes in familial nonmedullary t...
Pires, Carolina; Marques, Inês J.; Saramago, Ana; Moura, Margarida M.; Pojo, Marta; Cabrera, Rafael; Santos, Catarina; Rosário, Francisco; Lousa, DianaFunding Information: The authors are thankful to the patients and their families for their cooperation. The authors are thankful to Liga Portuguesa Contra o Cancro\u2014N\u00FAcleo Regional do Sul (LPCC\u2010NRS) that granted the researcher Marta Pojo. This study was funded by LPCC\u2010NRS, Televis\u00E3o Independente, Instituto Portugu\u00EAs de Oncologia de Lisboa Francisco Gentil \u2010 E.P.E (IPOLFG), iNOV...
A novel patient-derived cutaneous melanoma cell line reveals key features of me...
Tomás, Ana; Roque, Lúcia; Francisco, Inês; Silva, Ana Luísa; Nunes, Hugo; Gouveia, Emanuel; Carvalho, Elisabete; Farricha, Victor; Moura, CecíliaPublisher Copyright: Copyright © 2025 Tomás, Roque, Francisco, Silva, Nunes, Gouveia, Carvalho, Farricha, Moura, Rosa, Garrido, Albuquerque, Pereira, Cabral and Pojo.; Introduction: Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a small subset of patients relapses and progres...
BRD9 status is a major contributor for cysteine metabolic remodeling through MS...
Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; Oliva, Abel; C. Barral, DuartePublisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.; Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. ...
Clinical and molecular characterisation of metastatic papillary thyroid cancer ...
Simões-Pereira, Joana; Saramago, Ana; Rodrigues, Ricardo; Pojo, Marta; Pires, Carolina; Horta, Mariana; López-Presa, Dolores; Rito, MiguelFunding Information: This study was funded by iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344; UID/Multi/00462; UIDB/04462/2020), a program co-funded by Fundação para a Ciência e Tecnologia/Ministério da Ciência e do Ensino Superior, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo (SPEDM), and Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG). J.S.-P. was supported by i...
SPRY4 as a Potential Mediator of the Anti-Tumoral Role of Macrophages in Anapla...
Pinto, Ana Teresa; Pojo, Marta; Rodrigues, Ricardo; Sousa, Diana Pacheco; Matthiesen, Rune; Carvalho, Ana Sofia; Beck, Hans C.; Pires, CarolinaFunding Information: This work was funded by MERCK in collaboration with Grupo de Estudos da Tiroide (GET) from Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo (SPEDM) (MERCK/GET/SPEDM/2017), by Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020) and the Associate...
The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness
Cabaço, Luís C.; Tomás, Ana; Pojo, Marta; C. Barral, DuarteFunding Information: LC is funded by an FCT PhD fellowship (2020.08812.BD). AT is funded by an FCT PhD fellowship (2021.06204.BD). MP is funded by Liga Portuguesa Contra o Cancro – Núcleo Regional do Sul (LPCC-NRS). DB lab is supported by Fundação para a Ciência e a Tecnologia (FCT) through grant PTDC/BIA-CEL/29765/2017. This publication was funded by the iNOVA4Health - UIDB/04462/2020 and UIDP/04462/2020, a pr...
Unraveling the relevance of arl gtpases in cutaneous melanoma prognosis through...
Brito, Cheila; Costa‐silva, Bruno; C. Barral, Duarte; Pojo, MartaFunding Information: Funding: This research was funded by iNOVA4Health—UIDB/04462/2020, a program financially supported by the Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência. M.P. was funded by the Liga Portuguesa Contra o Cancro ‒ Núcleo Regional do Sul (LPCC‐NRS). D.B. was funded by the FCT Investigator Program (IF/00501/2014/CP1252/CT0001). Publisher Copyright: © 2021 by the authors. L...
High-throughput sequencing identifies 3 novel susceptibility genes for heredita...
Campos, Catarina; Fragoso, Sofia; Luís, Rafael; Pinto, Filipe; Brito, Cheila; Esteves, Susana; Pataco, Margarida; Santos, Sidónia; Machado, PatríciaFunding: The authors are thankful for the collaboration of all departments involved from IPOLFG, Lisboa, Portugal. F.P. received a grant from National Funds through the Foundation for Science and Technology (FCT), reference SFRH/BPD/115730/2016. The authors are thankful for the financial support to Liga Portuguesa Contra o Cancro, Núcleo Regional Sul (LPCC-NRS), IPOLFG, TVI (Televisão Independente) and iNOVA4He...
Take advantage of glutamine anaplerosis, the kernel of the metabolic rewiring i...
Martins, Filipa; Gonçalves, Luís G.; Pojo, Marta; Serpa, JacintaGlutamine is a non-essential amino acid that plays a key role in the metabolism of proliferating cells including neoplastic cells. In the central nervous system (CNS), glutamine metabolism is particularly relevant, because the glutamine-glutamate cycle is a way of controlling the production of glutamate-derived neurotransmitters by tightly regulating the bioavailability of the amino acids in a neuron-astrocyte ...
Subversion of Ras Small GTPases in Cutaneous Melanoma Aggressiveness
Brito, Cheila; C. Barral, Duarte; Pojo, MartaThe rising incidence and mortality rate associated with the metastatic ability of cutaneous melanoma represent a major public health concern. Cutaneous melanoma is one of the most invasive human cancers, but the molecular mechanisms are poorly understood. Moreover, currently available therapies are not efficient in avoiding melanoma lethality. In this context, new biomarkers of prognosis, metastasis, and respon...