12 documents found, page 1 of 2
PIK3CA Mutations
Tomás, Ana; Pojo, MartaGliomas are the most common and lethal malignant primary brain tumors in adults, associated with the highest number of years of potential life lost. The latest WHO classification for central nervous system tumors highlighted the need for new biomarkers of diagnosis, prognosis, and response to therapy. The PI3K/Akt signaling pathway is clearly implicated in tumorigenesis, being one of the most frequently altered...
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors...
Acúrcio, Rita C; Pozzi, Sabina; Carreira, Barbara; Pojo, Marta; Gómez-Cebrián, Nuria; Casimiro, Sandra; Fernandes, Adelaide; Barateiro, AndreiaBackground: Inhibiting programmed cell death protein 1 (PD-1) or PD-ligand 1 (PD-L1) has shown exciting clinical outcomes in diverse human cancers. So far, only monoclonal antibodies are approved as PD-1/PD-L1 inhibitors. While significant clinical outcomes are observed on patients who respond to these therapeutics, a large proportion of the patients do not benefit from the currently available immune checkpoint...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Lopes, Maria CelesteThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Celeste Lopes, MariaThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Gonçalves, Céline S.; Castro, Joana Isabel Martins Cosme Vieira; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro Filipe Monteiro; Chautard, EmmanuelGlioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were...
Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in gl...
Xavier-Magalhães, Ana; Oliveira, Ana Isabel Ferreira; de Castro, Joana Vieira; Pojo, Marta; Gonçalves, Céline S.; Lourenço, TatianaAbnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor ...
Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenot...
Gonçalves, Vera Mónica Miranda; Granja, Sara Costa; Martinho, Olga; Honavar, Mrinalini; Pojo, Marta; Costa, Bruno Marques; Pires, Manuel MeloBackground: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment through monocarboxylate transporters (MCTs). While hypoxia-mediated regulation of MCT4 has been characterized, the r...
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initia...
Pojo, Marta; Gonçalves, Céline S.; Magalhães, Ana Xavier; Oliveira, Ana Isabel; Gonçalves, Tiago; Correia, Sara; Rodrigues, Ana JoãoGlioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and survival. The prognostic value of HOXA9 in glioblastoma patients was validated in two large datasets from...
Transcriptional profiling of HOXA9-regulated genes in human glioblastoma cell m...
Gonçalves, Céline S.; Magalhães, Ana Xavier; Pojo, Marta; Oliveira, Ana Isabel; Reis, R. M.; Sousa, Nuno; Rocha, Miguel; Costa, Bruno MarquesThe data here described pertain to the article by Pojo et al. (2015) titled A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide (Pojo, Goncalves et al. 2015). HOX genes are part of the homeobox genes family, which encodes transcription factors crucial during embryonic development [6] and [9] and also in postdevelopmental regulation [...
HOXA9 promotes glioblastoma initiation, aggressiveness and resistance to therapy
Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Oliveira, Ana Isabel; Costa, Sandra Maria Araújo da; Pinto, Luísa; Reis, R. M.; Rocha, MiguelGlioblastoma is the most common and malignant subtype of glioma, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 may render glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and prognosis. Expression microarrays were used to identify HOXA9 target genes. Stable gl...