15 documents found, page 1 of 2

Radiotherapy metastatic prostate cancer cell lines treated with gold nanorods m...

MicroRNA (miRNA) modulation has been identified as a promising strategy for improving the response of human prostate cancer (PCa) to radiotherapy (RT). Studies have shown that mimics or inhibitors of miRNAs could modulate the sensitivity of PCa cells to RT. In addition, pegylated gold nanoparticles have been studied as a therapeutic approach to treat PCa cells and/or vehicles for carrying miRNAs to the inside o...

Gold nanoparticles as therapeutic agent for radiotherapy of PC3 prostate cancer...

Radiotherapy (RT) is a therapeutic modality that deliver a precise dose of ionizing radiation in a specific tumour volume, promoting the irradiation of tumor cells with as minimal damage as possible in surrounding normal tissues. Besides the evolution of equipment and technology, this therapy still has some problems related with radioresistance, which consequently increase the recurrence at 5 years. Over the ye...

Nanotheranostics with gold nanoparticles applied to Radiotherapy

Establishing a Link between Endothelial Cell Metabolism and Vascular Behaviour ...

Vascular complications contribute significantly to the extensive morbidity and mortality rates observed in people with diabetes. Despite well known that the diabetic kidney and heart exhibit imbalanced angiogenesis, the mechanisms implicated in this angiogenic paradox remain unknown. In this study, we examined the angiogenic and metabolic gene expression profile (GEP) of endothelial cells (ECs) isolated from a ...

Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes–associated oxidative ...

Galectin-3 (Gal3) expression is associated with accumulation of Advanced Glycation End products (AGE), a common feature in diabetes mellitus (DM). The role of Gal3 in oxidative stress is, however, controversial, being considered in the literature to play either a protective role or exacerbating disease. :Herein, we examined the interplay between Gal3 and oxidative stress in a high-fat diet -induced type 2 DMC57...

Alterações climáticas: risco e mudança social em três zonas costeiras de Portugal

Are we all on the same boat? The challenge of adaptation facing Portuguese coas...

The Portuguese coast is experiencing severe erosion and loss of beachfront, processes which are expected to become worse with climate change impacts. These additional alterations are beginning to show at a time when financing for conventional coastal protection is no longer guaranteed at scales of investment which are likely to be required if future coastlines are to be maintained. This paper looks at how resid...

Change in the way we live and plan the coast: stakeholders discussions on futur...

Justiça social e envolvimento das comunidades costeiras na adaptação às alteraç...

Mudança costeira em Portugal: perceções das comunidades, justiça social e democ...