6 documents found, page 1 of 1
THYROID AUTO-IMMUNITY AS A RISK FACTOR FOR RECURRENT MULTINODULAR GOITER AFTER ...
Borges, Filipe; Marques, Ricardo; Nascimento, Isabel; Raimundo, Luísa; Portugal, Jorge; Costa, Paulo MatosBackground. The ideal surgical strategy to multinodular goiter (MNG) is currently still matter of discussion. Thyroid auto- immunity is a well-known risk factor for hypothyroidism and could play a role in MNG’s physiopathology. Objective. Assess thyroid auto-immunity as a risk factor for MNG recurrence. Materials and Methods. Retrospective analysis of a 5-year (January 2012 – December 2016) prospective dat...
THE AETIOLOGY OF ACUTE APPENDICITIS. IS ALLERGY THE MISSING LINK? A NARRATIVE R...
Carvalho, Nuno; Borges, Filipe; Costa, Beatriz; Matos Costa, PauloAcute appendicitis is the most common abdominal surgical emergency. Since the work of Fitz in the XIX century it has been assumed that luminal obstruction is the main pathological event. However, this theory has been recently challenged by some new insights that suggest that an allergic reaction can be one of the possible causes or co-factors. The current knowledge on the aetiology of acute appendicitis was rev...
COMPARISON OF BISAP, NLR AND HAPS IN PREDICTING SEVERITY OF ACUTE PANCREATITIS,...
Borges, Filipe; Miranda, Joana; Silva, Sofia; Carvalho, Nuno; Matos Costa, PauloBackgrond. Early risk stratification is crucial in Acute Pancreatitis (AP). The BedSide Index for Severity in Acute Pancreatitis (BISAP) allows risk stratification at the time of hospital admission through a five-variable analysis. Several inflammatory markers have shown prognostic value in AP. Amongst them the Neutrophil to Lymphocyte Ratio has the best predictive accuracy. The Harmless Acute Pancreatitis Scor...
Transcriptional profiling of Arabidopsis root hairs and pollen defines an apica...
Becker, Jörg D; Takeda, Seiji; Borges, Filipe; Dolan, Liam; Feijó, José ACurrent views on the control of cell development are anchored on the notion that phenotypes are defined by networks of transcriptional activity. The large amounts of information brought about by transcriptomics should allow the definition of these networks through the analysis of cell-specific transcriptional signatures. Here we test this principle by applying an analogue to comparative anatomy at the cellular ...
Reprogramming of DNA Methylation in Pollen Guides Epigenetic Inheritance via Sm...
Calarco, Joseph P.; Borges, Filipe; Donoghue, Mark T.A.; Van Ex, Frédéric; Jullien, Pauline E.; Lopes, Telma; Gardner, Rui; Berger, FrédéricEpigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and found that unlike in mammals the plant germline retains CG and CHG DNA methylation. However, CHH...
FACS-based purification of Arabidopsis microspores, sperm cells and vegetative ...
Borges, Filipe; Gardner, Rui; Lopes, Telma; Calarco, Joseph P; Boavida, Leonor C; Slotkin, R; Martienssen, Robert A; Becker, Jörg DBackground: The male germline in flowering plants differentiates by asymmetric division of haploid uninucleated microspores, giving rise to a vegetative cell enclosing a smaller generative cell, which eventually undergoes a second mitosis to originate two sperm cells. The vegetative cell and the sperm cells activate distinct genetic and epigenetic mechanisms to control pollen tube growth and germ cell specifica...