3 documents found, page 1 of 1
Optimized Separation Method for Estriol, 17-β-Estradiol and Progesterone by Cap...
Marques,Rafael; Vaz,Fernando A. S.; Polonini,Hudson C.; Oliveira,Marcone A. L. deA monolithic stationary phase based on 3-(methacryloxypropyl)trimethoxysilane monomer, prepared within a fused silica capillary externally coated with a UV-transparent fluoropolymer was employed for separation of estriol, 17-b-estradiol and progesterone by capillary electrochromatography in a standard mixture. A 23 factorial design was used to optimize the separation system. The optimized condition containing 3...
Synthesis and evaluation of octocrylene-inspired compounds for UV-filter activity
Polonini,Hudson C.; Lopes,Rosângela S.; Beatriz,Adilson; Gomes,Roberto S.; Silva,Adriano O.; Lima,Ricardo V. de; Nunes,Gláucia. A.Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) r...
Transdermal formulations containing human sexual steroids: development and vali...
Polonini,Hudson C.; Soldati,Pedro Paulo; Oliveira,Marcone Augusto Leal de; Brandão,Marcos Antônio F.; Chaves,Maria das Graças M.; Raposo,Nádia R. B.In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. For this purpose, novel high-performance liquid chromatography methods were developed and validated in an eco-friendly manner and used to determine the in vitro release of such products. The methods were suitable for our intended g...