Encontrados 23 documentos, a visualizar página 1 de 3
String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegeneration
Oliveira, Andreia C.; Santos, Madalena; Pinho, Mafalda; Lopes, Carla S.Tau pathology is defined by the intracellular accumulation of abnormally phosphorylated Tau (MAPT) and is prevalent in several neurodegenerative disorders. The identification of modulators of Tau abnormal phosphorylation and aggregation is key to understanding disease progression and developing targeted therapeutic approaches. In this study, we identified String (Stg)/Cdc25 phosphatase as a suppressor of abnorm...
Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodg...
Borges, Vítor; Isidro, Joana; Cunha, Mário; Cochicho, Daniela; Martins, Luís; Banha, Luís; Figueiredo, Margarida; Rebelo, Leonor; Trindade, Maria CéuRecent studies have shown that persistent SARS-CoV-2 infections in immunocompromised patients can trigger the accumulation of an unusual high number of mutations with potential relevance at both biological and epidemiological levels. Here, we report a case of an immunocompromised patient (non-Hodgkin lymphoma patient under immunosuppressive therapy) with a persistent SARS-CoV-2 infection (marked by intermittent...
High-intensity infrasound effects on glucose metabolism in rats
Pereira, Gonçalo Martins; Santos, Madalena; Pereira, Sofia S.; Borrecho, Gonçalo; Tortosa, Francisco; Brito, José; Freitas, DiamantinoRecent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar...
Effects of high-intensity infrasound on liver lipid content of rats
Pereira, Gonçalo Martins; Pereira, Sofia S.; Santos, Madalena; Brito, José; Freitas, Diamantino; Carvalho, António Oliveira de; Águas, ArturPrevious experimental studies show that exposure to noise with high and audible frequencies causes multiple metabolic alterations, such as increased liver glycogen and triglycerides. However, the effect of exposure to sound with lower frequencies, such as high-intensity infrasound (frequency <20 Hz and sound pressure level >90 dB), on the liver lipid content is still unclear. As such, we aimed to study the effe...
High‐grade urothelial carcinoma in a kidney transplant recipient after JC virus...
Querido, Sara; Fernandes, Isabel; Weigert, Andre; Casimiro, Sandra; Albuquerque, Catarina; Ramos, Sância; Adragão, Teresa; Luz, Ivan; Paixão, PauloKidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high-grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation...
Improving access to community-based pulmonary rehabilitation: 3R protocol for r...
Marques, Alda; Jácome, Cristina; Rebelo, Patrícia; Paixão, Cátia; Oliveira, Ana; Cruz, Joana; Freitas, Célia; Rua, Marília; Loureiro, HelenaPulmonary rehabilitation (PR) has demonstrated patients' physiological and psychosocial improvements, symptoms reduction and health-economic benefits whilst enhances the ability of the whole family to adjust to illness. However, PR remains highly inaccessible due to lack of awareness of its benefits, poor referral and availability mostly in hospitals. Novel models of PR delivery are needed to enhance its implem...
Improving access to community-based pulmonary rehabilitation: 3R protocol for r...
Marques, Alda; Jácome, Cristina; Rebelo, Patrícia; Paixão, Cátia; Oliveira, Ana; Cruz, Joana; Freitas, Célia; Rua, Marília; Loureiro, HelenaBackground: Pulmonary rehabilitation (PR) has demonstrated patients’ physiological and psychosocial improvements, symptoms reduction and health-economic benefits whilst enhances the ability of the whole family to adjust to illness. However, PR remains highly inaccessible due to lack of awareness of its benefits, poor referral and availability mostly in hospitals. Novel models of PR delivery are needed to enhanc...
Digital technology access among patients with chronic respiratory diseases
Jácome, Cristina; Marques, Fábio; Paixão, Cátia; Rebelo, Patrícia; Oliveira, Ana; Cruz, Joana Patrícia; Freitas, Célia; Rua, Marília; Loureiro, HelenaPulmonary rehabilitation (PR) is an evidence-based intervention to manage chronic respiratory diseases (CRD), but its benefits diminish over time. Web-based approaches may have a key-role in supporting patients to comply with their maintenance action plan, if familiarity with this technology exist. This study explored if patients with CRD have access to digital technology and if they feel confident in using it....
Reflexões sobre Ambiente, Território e Sociedade: Três Anos do Blogue ATS
Ferrão, João; Delicado, Ana; Horta, Ana; Gomes, Carla; Travassos, David; Rowland, Jussara; Santos, Madalena; Tulumello, SimoneO Blogue ATS é alimentado e gerido pelos membros do grupo de investigação Ambiente, Território e Sociedade (GIATS) do Instituto de Ciências Sociais da Universidade de Lisboa. O seu objetivo é duplo: proporcionar um espaço de difusão, debate e teste de ideias nas áreas de interesse do grupo; e dar relevo às dimensões do trabalho do grupo que tenham interesse para públicos não-académicos. Os textos podem ser publ...
Respiratory infections in elderly people: Viral role in a resident population o...
Chasqueira, Maria-Jesus; Paixão, Paulo; Rodrigues, Maria-Lúcia; Piedade, Cátia; Caires, Iolanda; Palmeiro, Teresa; Botelho, Maria-AmaliaObjective: The aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents. Methods: Nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1–4, adenovirus, hu...