12 documents found, page 1 of 2
Longitudinal study of ESBL/AmpC-producing Enterobacterales strains sharingbetwe...
Menezes, Juliana; Frosini, Siân-Marie; Belas, Adriana; Marques, Cátia; Silva, Joana; Amaral, Andreia; Loeffler, Anette; Pomba, ConstançaExtended-spectrum beta-lactamase (ESBL)- and plasmid-mediated cephalosporinase (AmpC)-producing Enterobacterales (ESBL/AmpC-E) are an increasing healthcare problem in both human and veterinary medicine. The aim of this study was to investigate the possible sharing of ESBL/AmpC-E strains between healthy companion animals and humans of the same household in Portugal (PT) and the United Kingdom (UK). In a prospect...
Carbapenemase-producing Enterobacterales strains causing infections in companio...
Silva, Joana; Menezes, Juliana; Fernandes, Laura; Costa, Sofia; Amaral, Andreia; Pomba, ConstançaAn increase in Klebsiella pneumoniae carbapenem-resistant human nosocomial strains is occurring in Europe, namely with the blaOXA-48-like and blaKPC-like genes. We determined the prevalence of carbapenemase-producing Enterobacterales clinical strains in companion animals in Portugal and characterized their mobile genetic elements. Susceptibility data of a consecutive collection of 977 Enterobacterales clinical ...
Transmission Dynamics of ESBL/AmpC and Carbapenemase-Producing Enterobacterales...
Menezes, Juliana; Frosini, Sian-Marie; Weese, Scott; Perreten, Vicent; Schwarz, Stephan; Amaral, Andreia; Loeffler, Anette; Pomba, ConstançaAntimicrobial resistance mediated by extended-spectrum beta-lactamase (ESBL)- and plasmid-mediated cephalosporinase (AmpC)-producing Enterobacterales, as well as carbapenemase-producing Enterobacterales have globally increased among companion animals, posing a potential health risk to humans in contact with them. This prospective longitudinal study investigates the transfer of ESBL/AmpC- and carbapenemase-produ...
The impact of efflux on reduced susceptibility to biocides and fluoroquinolone ...
Leal, Marta; Pomba, Constança; Morais, Catarina; Costa, Sofia Santos; Ramos, Bárbara; Couto, Isabel; Abrantes, PatríciaStaphylococcus pseudintermedius is the main bacterial agent causing skin and soft tissue infections (SSTIs) in companion animals. The increasing resistance to antimicrobial compounds, associated with multidrug resistance phenotypes, poses a risk for the therapeutic control of skin infections caused by this pathogenic agent. Until now, efflux as a resistance mechanism has been overlooked for this species. The ai...
Molecular epidemiology of Clostridioides difficile in companion animals: Geneti...
Alves, Frederico; Castro, Rita; Pinto, Miguel; Nunes, Alexandra; Pomba, Constança; Oliveira, Manuela; Silveira, Leonor; Gomes, João PauloIntroduction: The changing epidemiology of Clostridioides difficile reflects a well-established and intricate community transmission network. With rising numbers of reported community-acquired infections, recent studies tried to identify the role played by non-human reservoirs in the pathogen's transmission chain. This study aimed at describing the C. difficile strains circulating in canine and feline populatio...
Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospi...
Spadar, Anton; Phelan, Jody; Elias, Rita; Modesto, Ana; Caneiras, Cátia; Marques, Cátia; Lito, Luís; Pinto, Margarida; Cavaco‑Silva, PatríciaKlebsiella pneumoniae (Kp) bacteria are an increasing threat to public health and represent one of the most concerning pathogens involved in life-threatening infections and antimicrobial resistance (AMR). To understand the epidemiology of AMR of Kp in Portugal, we analysed whole genome sequencing, susceptibility testing and other meta data on 509 isolates collected nationwide from 16 hospitals and environmental...
KPC-3-producing Klebsiella pneumoniae sequence type 392 from a dog’s clinical i...
Moreira da Silva, Joana; Menezes, Juliana; Mendes, Gabriel; Santos Costa, Sofia; Caneiras, Catia; Poirel, Laurent; Amaral, Andreia J.; Pomba, ConstançaResistance to carbapenems in Enterobacterales poses a threat to health care systems worldwide since those infections are associated with high mortality and limited treatment options. The latest European reports show that some southern European countries are almost endemic for carbapenemase-producing Enterobacterales (CPEs). Mirroring the European tendency, Portugal has been observing a steady increase in the oc...
ESBL/pAmpC-producing Escherichia coli causing urinary tract infections in non-r...
Belas, Adriana; Marques, Cátia; Menezes, Juliana; Gama, Luís Telo da; Cavaco-Silva, Patrícia; Pomba, ConstançaUrinary tract infections (UTI) caused by Escherichia coli are frequently diagnosed in humans and companion animals. Extended-spectrum beta-lactamase (ESBL)- and cephalosporinase (pAmpC)-producing Escherichia coli are worldwide-disseminated and frequently multidrug-resistant, hence leading to treatment failure and public health concerns. This study aimed to characterize and compare ESBL/pAmpC-producing E. coli s...
Human and companion animal Proteus mirabilis sharing
Marques, Cátia; Belas, Adriana; Menezes, Juliana; Silva, Joana Moreira da; Cavaco-Silva, Patrícia; Trigueiro, Graça; Gama, Luís T.; Pomba, ConstançaProteus mirabilis is an important pathogen that is associated with urinary tract infections. This study aims to determine the colonization and sharing of P. mirabilis between healthy companion animals and humans that are living together and to evaluate the clonal relatedness of the fecal and clinical stains. Eighteen households (24 humans, 18 dogs, 8 cats) with at least one human–animal pair were studied. Fecal...
Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospi...
Spadar, Anton; Phelan, Jody; Elias, Rita; Modesto, Ana; Caneiras, Cátia; Marques, Cátia; Lito, Luís; Pinto, Margarida; Cavaco-Silva, PatríciaKlebsiella pneumoniae (Kp) bacteria are an increasing threat to public health and represent one of the most concerning pathogens involved in life-threatening infections and antimicrobial resistance (AMR). To understand the epidemiology of AMR of Kp in Portugal, we analysed whole genome sequencing, susceptibility testing and other meta data on 509 isolates collected nationwide from 16 hospitals and environmental...