14 documents found, page 1 of 2
Genetics of Parkinson’s disease in Brazil: a systematic review of monogenic forms
Santos-Lobato,Bruno L.; Schumacher-Schuh,Artur; Mata,Ignacio F.; Letro,Grace H.; Braga-Neto,Pedro; Brandão,Pedro R. P.; Godeiro-Junior,Clécio O.ABSTRACT Background: Increasing numbers of mutations causing monogenic forms of Parkinson's disease (PD) have been described, mostly among patients in Europe and North America. Since genetic architecture varies between different populations, studying the specific genetic profile of Brazilian patients is essential for improving genetic counseling and for selecting patients for clinical trials. Objective: We cond...
Acute cerebellar ataxia: differential diagnosis and clinical approach
Pedroso,José Luiz; Vale,Thiago Cardoso; Braga-Neto,Pedro; Dutra,Lívia Almeida; França Jr,Marcondes Cavalcante; Teive,Hélio A. G.ABSTRACT Cerebellar ataxia is a common finding in neurological practice and has a wide variety of causes, ranging from the chronic and slowly-progressive cerebellar degenerations to the acute cerebellar lesions due to infarction, edema and hemorrhage, configuring a true neurological emergency. Acute cerebellar ataxia is a syndrome that occurs in less than 72 hours, in previously healthy subjects. Acute ataxia u...
Cross-cultural adaptation and validation of the International Cooperative Ataxi...
Maggi,Fernanda Aparecida; Braga-Neto,Pedro; Chien,Hsin Fen; Gama,Maria Thereza Drumond; Rezende Filho,Flávio Moura; Saraiva-Pereira,Maria LuizaABSTRACT Introduction: The clinical assessment of patients with ataxias requires reliable scales. We aimed to translate, adapt and validate the International Cooperative Ataxia Rating Scale (ICARS) into Brazilian Portuguese. Methods: The steps of this study were forward translation, translation synthesis, backward translation, expert committee meeting, preliminary pilot testing and final assessment. Thirty pati...
Neurological complications of solid organ transplantation
Pedroso,José Luiz; Dutra,Lívia Almeida; Braga-Neto,Pedro; Abrahao,Agessandro; Andrade,João Brainer Clares de; Silva,Gabriel Lopes daABSTRACT Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is b...
Encephalitis associated with the chikungunya epidemic outbreak in Brazil: repor...
Pereira,Licia Pacheco; Villas-Bôas,Rafaela; Scott,Stephanie Suzanne de Oliveira; Nóbrega,Paulo Ribeiro; Sobreira-Neto,Manoel AlvesAbstract Chikungunya, an alphavirus infection presenting with fever, rash, and polyarthritis, is most often an acute febrile illness. Neurologic complications of chikungunya infection have been reported. Here we report the clinical and neuroimaging data of 2 patients with chikungunya-associated encephalitis during the recent Brazilian epidemic.
Clinical spectrum of early onset cerebellar ataxia with retained tendon reflexe...
Pedroso,Jose Luiz; Braga-Neto,Pedro; Ricarte,Irapua Ferreira; Albuquerque,Marcus Vinicius Cristino; Barsottini,Orlando Graziani PovoasAutosomal recessive cerebellar ataxias are a heterogeneous group of neurological disorders. In 1981, a neurological entity comprised by early onset progressive cerebellar ataxia, dysarthria, pyramidal weakness of the limbs and retained or increased upper limb reflexes and knee jerks was described. This disorder is known as early onset cerebellar ataxia with retained tendon reflexes. In this article, we aimed to...
Patients with autosomal dominant spinocerebellar ataxia have more risk of falls...
Aizawa,Carolina Yuri P.; Pedroso,Jose Luiz; Braga-Neto,Pedro; Callegari,Marilia Rezende; Barsottini,Orlando Graziani PovoasOBJECTIVES: To assess balance and ability to function in patients with spinocerebellar ataxia. METHODS: A total of 44 patients with different spinocerebellar ataxia types 1, 2, 3, and 6 were evaluated using the Tinetti balance and gait assessment and the functional independence measure. The scale for the assessment and rating of ataxia and the international cooperative ataxia rating scale were used to evaluate ...
Sneddon's syndrome: case report and review of its relationship with antiphospho...
Dutra,Livia Almeida; Braga-Neto,Pedro; Pedroso,José Luiz; Barsottini,Orlando Graziani PovoasThe Sneddon's syndrome is a rare disorder characterized by the occurrence of cerebrovascular disease associated with livedo reticularis. The antiphospholipid syndrome is the most frequent type of acquired thrombophilia, defined by the occurrence of thrombosis or pregnancy morbidity in the presence of persistently positive antiphospholipid antibodies. Approximately 80% of Sneddon's syndrome patients have an anti...
Neurosarcoidosis: guidance for the general neurologist
Dutra,Lívia Almeida; Braga-Neto,Pedro; Oliveira,Ricardo Araújo; Pedroso,José Luiz; Abrahão,Agessandro; Barsottini,Orlando Graziani PovoasNeurosarcoidosis (NS) more commonly occurs in the setting of systemic disease. The diagnosis is based on a clinical history suggestive of NS, presence of noncaseating granulomas, and supportive evidence of sarcoid pathology, laboratory, and imaging studies. NS could involve any part of the nervous system and often demands high doses of steroids for symptom control. It presents low response to isolated steroids ...
Machado-Joseph disease in Brazil: from the first descriptions to the emergence ...
Pedroso,José Luiz; Braga-Neto,Pedro; Radvany,João; Barsottini,Orlando Graziani PovoasMachado-Joseph disease is an autosomal dominant inherited disorder of Azorean ancestry firstly described in 1972. Since then, several Brazilian researchers have studied clinical and genetic issues related to the disease. Nowadays, Machado-Joseph disease is considered the most common spinocerebellar ataxia worldwide. Machado-Joseph disease still has no specific therapy to arrest progression, but the unclear path...