5 documents found, page 1 of 1
XRCC4 rs28360071 intronic variant is associated with increased risk for infant ...
Louzada-Neto,Orlando; Lopes,Bruno A.; Brisson,Gisele D.; Andrade,Francianne G.; Cezar,Ingrid S.; Santos-Rebouças,Cíntia B.; Albano,Rodolpho M.Abstract Early age acute leukemia (EAL) shows a high frequency of KMT2A-rearrangements (KMT2A-r). Previous investigations highlighted double-strand breaks arising from maternal exposure to xenobiotics during pregnancy as a risk factor for EAL and KMT2A-r. In this case-control study, we investigated the relationship between EAL and genetic variants of the nonhomologous end-joining (XRCC6 rs5751129, XRCC4 rs68693...
Mother and child characteristics at birth and early age leukemia: a case-cohort...
Reis,Rejane de Souza; Silva,Neimar de Paula; Santos,Marceli de Oliveira; Oliveira,Julio Fernando Pinto; Thuler,Luiz Claudio Santos; Camargo,Beatriz deAbstract Objective: The population-based cancer registries (PBCR) and the Information System on Live Births in Brazil (Sistema de Informações sobre Nascidos Vivos [SINASC]) have information that enables the test for risk factors associated with leukemia at an early age. The aim of this study was to identify maternal and birth characteristics associated with early-age acute leukemia (EAL) in Brazil. Methods: A c...
Identification of the MYST3-CREBBP fusion gene in infants with acute myeloid le...
Andrade,Francianne Gomes; Noronha,Elda Pereira; Baseggio,Rosania Maria; Fonseca,Teresa Cristina Cardoso; Freire,Bruno Marcelo RochaABSTRACT Background: Acute myeloid leukemia presenting the MYST3-CREBBP fusion gene is a rare subgroup associated with hemophagocytosis in early infancy and monocytic differentiation. The aim of this study was to define the relevant molecular cytogenetic characteristics of a unique series of early infancy acute myeloid leukemia cases (≤24 months old), based on the presence of hemophagocytosis by blast cells at ...
The concurrent occurrence of Leishmania chagasi infection and childhood acute l...
Vasconcelos,Gisele Moledo de; Azevedo-Silva,Fernanda; Thuler,Luiz Claudio dos Santos; Pina,Eugênia Terra Granado; Souza,Celeste S.F.; Calabrese,KatiaObjective: This study investigated the co-existence of Leishmania chagasi infection and childhood leukemia in patients naïve to treatment; this has serious clinical and epidemiological implications. Methods: The seroprevalence of L. chagasi antibodies prior to any treatment was investigated in children with clinical features of acute leukemia. Serological tests were performed in 470 samples drawn from under 14-...
Biological diversity variations of pediatric acute leukemia in Brazil: contribu...
Pombo-de-Oliveira,Maria S.; Cordoba,José C.; Alencar,Dora M.; Campos,Mércia M.; Carriço,Kadma; Dobbin,Jane; Dorea,Maria D.; Ferreira,ReginaWe describe the demographic and biological characteristics of 1,459 children with acute leukemia in Brazil to compare the effect of immunophenotypic differences with environmental factors that might be involved in the etiology of acute lymphoblastic leukemia (ALL). Combined morphological and immunological classifications were available for 96% of cases. Of these, 55% were B cell precursor ALL comprising pro-B A...