4 documents found, page 1 of 1
Portuguese recommendations for the use of ultrasound in rheumatology
Polido-Pereira, J; Serra, S; Teixeira, F; Ponte, C; Cerqueira, M; Cruz, M; Araújo, F; Barros, R; Costa, T; Santos-Faria, D; Lopes, C; Madruga-Dias, JNTRODUCTION: Ultrasound (US) is a relatively cheap, easily available and reliable method to improve the care of rheumatic patients. However, its use in rheumatology practice is very heterogeneous and needs to be standardized. OBJECTIVES: To develop recommendations for the use of US in rheumatic diseases endorsed by the Portuguese Society of Rheumatology. METHODS: A systematic literature review of the available ...
Systematic Literature Review Informing the 2018 Update of the EULAR Recommendat...
Monti, S; Águeda, A; Luqmani, R; Buttgereit, F; Cid, M; Dejaco, C; Mahr, A; Ponte, C; Salvarani, C; Schmidt, W; Hellmich, BObjectives: To analyse the current evidence for the management of large vessel vasculitis (LVV) to inform the 2018 update of the EULAR recommendations. Methods: Two systematic literature reviews (SLRs) dealing with diagnosis/monitoring and treatment strategies for LVV, respectively, were performed. Medline, Embase and Cochrane databases were searched from inception to 31 December 2017. Evidence on imaging was e...
Two Separate Effects Contribute to Regulatory T Cell Defect in Systemic Lupus E...
Costa, N; Marques, O; Godinho, SI; Carvalho, C; Leal, B; Figueiredo, AM; Vasconcelos, C; Marinho, A; Moraes-Fontes, MF; Gomes da Costa, A; Ponte, CForkhead box P3 (FoxP3)+ regulatory T cells (Tregs ) are functionally deficient in systemic lupus erythematosus (SLE), characterized by reduced surface CD25 [the interleukin (IL)-2 receptor alpha chain]. Low-dose IL-2 therapy is a promising current approach to correct this defect. To elucidate the origins of the SLE Treg phenotype, we studied its role through developmentally defined regulatory T cell (Treg ) su...
A3.6 Two components contributing to reduced treg surface CD25 in sle patients a...
Costa, N; Marques, O; Godinho, S; Carvalho, C; Leal, B; Vasconcelos, C; Marinho, A; Moraes-Fontes, M F; Gomes da Costa, A; Ponte, C; Marques, RBackground FOXP3+ regulatory T-cells (Tregs) in Systemic Lupus Erythematosus (SLE) are in a functionally deficient state with a characteristic reduction or absence of surface CD25 (the IL-2 receptor alpha chain). Genetic variation in the CD25-encoding IL2RA locus is associated with other autoimmune disorders.