4 documents found, page 1 of 1
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes Filho, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian ® Polaris C18 analytical column (3 m m, 50 x 2.0 mm) and pre-column Securityguard...
Estudo de equivalência farmacêutica dos fármacos captopril e cloridrato de prop...
Pontes, Andréa VieiraThe pharmaceutical equivalence between two medicines is based on the confirmation that both contain the same active drug on the same dosage and dosage form, wich is assessed by in vitro tests. In Brazil, the National Health Surveillance Agency defines that allopathic medicines can be registered in three categories: innovator, generic and similar drugs. The actual legislation determines that to register new gene...
Toxicology and safety of the tincture of Operculina alata in patients with func...
Santos, Luciana Kelly Ximenes dos; Cunha, Gilmara Holanda da; Fechine, Francisco Vagnaldo; Pontes, Andréa Vieira; Oliveira, Jonaina Costa deThe tincture of Operculina alata, popularly known as "tincture of jalapa", is used in Northeast Brazil to treat constipation and encephalic vascular accident, but it has not yet been adequately tested for safety and efficacy. The aim of this study was to evaluate the toxicology and safety of the tincture of O. alata in patients with functional constipation. This was a double-blind, randomized, placebo-controlle...
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian® Polaris C18 analytical column (3 μm, 50 x 2.0 mm) and pre-column Securitygu...