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Nanoencapsulation of gla-rich protein (GRP) as a novel approach to target infla...

Viegas, Carla S. B.; Araújo, Nuna; Carreira, Joana; Pontes, Jorge F.; Macedo, Anjos L.; Vinhas, Maurícia; Moreira, Ana S.; Faria, Tiago Q.; Grenha, Ana

Chronic inflammation is a major driver of chronic inflammatory diseases (CIDs), with a tremendous impact worldwide. Besides its function as a pathological calcification inhibitor, vitamin K-dependent protein Gla-rich protein (GRP) was shown to act as an anti-inflammatory agent independently of its gamma-carboxylation status. Although GRP’s therapeutic potential has been highlighted, its low solubility at physio...


Nanoencapsulation as a novel delivery approach for therapeutic applications of ...

Araújo, Nuna; Viegas, Carla; Pontes, Jorge F.; Marreiros, Catarina; Raimundo, Pedro; Macedo, Anjos L.; Matos, António Alves de; Grenha, Ana


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