3 documents found, page 1 of 1
In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therap...
Carvalho, Luísa; Lima, Fábio Pedroso de; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; Costa, Marta D.Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance. Considering that chromene-based scaffolds proved to be attractive candidates for cancer therapy, herein we prepared new chromeno[2,3-d]pyrimidinone derivatives by a simple two step procedure, sta...
Selective cytotoxicity of Portuguese propolis ethyl acetate fraction towards re...
Freitas, Ana Sofia; Costa, Marta Sílvia Freitas; Pontes, Olívia; Seidel, Veronique; Proença, M. Fernanda R. P.; Cardoso, Susana M.Renal cell carcinoma is the most lethal cancer of the urological system due to late diagnosis and treatment resistance. Propolis, a beehive product, is a valuable natural source of compounds with bioactivities and may be a beneficial addition to current anticancer treatments. A Portuguese propolis sample, its fractions (<i>n</i>-hexane, ethyl acetate, <i>n</i>-butanol and water) and three subfractions (<b>P1</b...
Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment
Pontes, Olívia; Costa, Marta Sílvia Freitas; Santos, Filipa; Marques, Maria Belém Sousa Sampaio; Dias, Tatiana Alexandra Freitas PerdigãoChalcone and chromene derivatives were synthesized in good yield through simple and effective reactions using innocuous solvents such as water and ethanol and high yielding aldol condensations. Generally, the reactions were performed at room temperature, leading to the isolation of highly pure compounds. These compounds were tested on breast cancer cells (MCF-7 and Hs578T) and breast non-neoplastic cells (MCF-1...