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Rationally designed dendritic silica nanoparticles for oral delivery of exenatide
Abeer, MM; Meka, AK; Pujara, N; Kumeria, T; Strounina, E; Nunes, R; Costa, A; Sarmento, B; Hasnain, SZ; Ross, BP; Popat, AType 2 diabetes makes up approximately 85% of all diabetic cases and it is linked to approximately one-third of all hospitalisations. Newer therapies with long-acting biologics such as glucagon-like peptide-1 (GLP-1) analogues have been promising in managing the disease, but they cannot reverse the pathology of the disease. Additionally, their parenteral administration is often associated with high healthcare c...
Date: 2019
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Origin: Repositório Aberto da Universidade do Porto