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Telomerase promoter mutations in cancer: an emerging molecular biomarker?

Vinagre, João; Pinto, Vasco; Celestino, Ricardo; Reis, Marta; Populo, H; Boaventura, Paula; Melo, Miguel; Catarino, T.; Lima, Jorge; Lopes, José Manuel

Cell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomerase reactivation, such immortalization could be due to telomere maintenance through the “alternative mechanism of telomere lengthening” (ALT) but the mechanisms underlying both forms of reactivation remained elusive. Mutations in the coding region of telomerase gene are very rare in the cancer setting,...

Date: 2014   |   Origin: Repositório Científico do Instituto Politécnico do Porto
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